Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK4 | Q13043 | 16/20 | 0.53 |
| ▸ | AURKA | O14965 | 3/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.53 |
| ▸ | DCLK1 | O15075 | 2/20 | 0.53 |
| ▸ | STK3 | Q13188 | 2/20 | 0.53 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | TYK2 | P29597 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.53 |
| ▸ | RIPK4 | P57078 | 1/20 | 0.53 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.53 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.53 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.53 |
| ▸ | MAP3K3 | Q99759 | 1/20 | 0.53 |
| ▸ | TAOK3 | Q9H2K8 | 1/20 | 0.53 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.53 |
| ▸ | TAOK2 | Q9UL54 | 1/20 | 0.53 |
| ▸ | MAP3K2 | Q9Y2U5 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20628525 | 0.77 | AURKA (0.69) | STK4AURKAPIK3CGAURKBDCLK1 | |
| SCHEMBL20628511 | 0.70 | DCLK1 (0.60) | STK4AURKAPIK3CGAURKBDCLK1 | |
| SCHEMBL24687407 | 0.70 | STK4 (0.57) | STK4AURKAPIK3CGAURKBDCLK1 | |
| SCHEMBL20628276 | 0.69 | PIK3CG (0.57) | STK4AURKAPIK3CGAURKBDCLK1 | |
| SCHEMBL20609709 | 0.69 | STK4 (1.00) | STK4AURKAPIK3CGAURKBDCLK1 | |
| SCHEMBL29366935 | 0.69 | STK4 (1.00) | STK4AURKAPIK3CGAURKBDCLK1 | |
| SCHEMBL24071018 | 0.69 | STK4 (0.65) | STK4AURKAPIK3CGAURKBDCLK1 | |
| SCHEMBL10098763 | 0.69 | PIK3CG (1.00) | STK4AURKAPIK3CGAURKBDCLK1 | |
| SCHEMBL21938547 | 0.67 | PIK3CD (0.70) | AURKAPIK3CGAURKBDCLK1STK3 | |
| SCHEMBL23998724 | 0.67 | STK4 (1.00) | STK4AURKAPIK3CGAURKBDCLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3424929-A1 | PYRIMIDINE SEVEN-MEMBERED-RING COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USES THEREOF | Anhui New Star Pharmaceutical Development Co., Ltd (CN) | 2019-01-09 | — | — | EP | disclosed |