Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC2 | Q92769 | 8/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20629473 | 0.91 | HDAC2 (0.49) | HDAC2HDAC6HDAC8HDAC3HDAC1 | |
| SCHEMBL20629509 | 0.90 | HDAC2 (0.46) | HDAC2HDAC6HDAC8HDAC3HDAC1 | |
| SCHEMBL20635876 | 0.88 | MEN1 (0.36) | — | |
| SCHEMBL20605349 | 0.81 | HDAC6 (0.44) | HDAC2HDAC6HDAC8HDAC3HDAC1 | |
| SCHEMBL20629511 | 0.78 | HDAC2 (0.51) | HDAC2HDAC6HDAC8HDAC3HDAC1 | |
| SCHEMBL20629253 | 0.78 | HDAC2 (0.42) | HDAC2HDAC6HDAC8HDAC3HDAC1 | |
| SCHEMBL20635567 | 0.77 | HDAC6 (0.80) | HDAC2HDAC6HDAC8HDAC3HDAC1 | |
| SCHEMBL20634168 | 0.77 | HDAC6 (0.80) | HDAC2HDAC6HDAC8HDAC3HDAC1 | |
| SCHEMBL20634791 | 0.77 | HDAC6 (0.80) | HDAC2HDAC6HDAC8HDAC3HDAC1 | |
| SCHEMBL22487621 | 0.77 | HDAC2 (0.52) | HDAC2HDAC6HDAC8HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3424925-A1 | NOVEL HDAC6 INHIBITORS, WITH IMPROVED SOLUBILITY AND THEIR USES | Universität Regensburg (DE) | 2019-01-09 | — | — | EP | disclosed |