Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 14/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20610413 | 0.85 | ATF4 (0.74) | ATF4KDM4EMAPTMEN1KMT2A | |
| SCHEMBL20974142 | 0.81 | ATF4 (1.00) | ATF4MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL20610367 | 0.80 | ATF4 (0.86) | ATF4MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL23182497 | 0.80 | ATF4 (0.76) | ATF4KMT2ANPC1TSHRRAB9A | |
| SCHEMBL20610456 | 0.79 | ATF4 (0.80) | ATF4MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL20610335 | 0.79 | ATF4 (0.70) | ATF4KDM4EMAPTMEN1KMT2A | |
| SCHEMBL20610386 | 0.78 | ATF4 (0.82) | ATF4MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL20610315 | 0.78 | ATF4 (0.82) | ATF4MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL20610415 | 0.78 | ATF4 (0.72) | ATF4MEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL20610318 | 0.78 | ATF4 (0.86) | ATF4MEN1KMT2AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019008506-A1 | N-(3-(2-(4-CHLOROPHENOXY)ACETAMIDO)BICYCLO[1.1.1]PENTAN-1-YL)-2-CYCLOBUTANE-1-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ATF4 INHIBITORS FOR TREATING CANCER AND OTHER DISEASES | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-01-10 | — | — | WO | disclosed |