Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20631489 | 0.99 | ALDH1A1 (0.50) | ALDH1A1HPGDHSD17B10KDM4EMEN1 | |
| SCHEMBL20632583 | 0.85 | ALDH1A1 (0.48) | ALDH1A1HPGDHSD17B10KDM4EMEN1 | |
| SCHEMBL20631536 | 0.81 | NOTUM (0.38) | ALDH1A1HPGDHSD17B10KDM4EMEN1 | |
| SCHEMBL610163 | 0.79 | ALDH1A1 (0.60) | ALDH1A1HPGDHSD17B10KDM4EMEN1 | |
| SCHEMBL609036 | 0.79 | ALDH1A1 (0.60) | ALDH1A1HPGDHSD17B10KDM4EMEN1 | |
| SCHEMBL611101 | 0.78 | ALDH1A1 (0.62) | ALDH1A1HPGDHSD17B10KDM4EMEN1 | |
| SCHEMBL8349198 | 0.73 | ALDH1A1 (0.70) | ALDH1A1HPGDHSD17B10KDM4EMEN1 | |
| SCHEMBL610308 | 0.72 | ALDH1A1 (0.63) | ALDH1A1HPGDHSD17B10KDM4EMEN1 | |
| SCHEMBL16612626 | 0.72 | ALDH1A1 (0.63) | ALDH1A1HPGDHSD17B10KDM4EMEN1 | |
| SCHEMBL11738763 | 0.71 | ALDH1A1 (0.72) | ALDH1A1HPGDHSD17B10KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2997029-B1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2019-01-09 | — | — | EP | disclosed |