Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 15/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.42 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.40 |
| ▸ | RHEB | Q15382 | 2/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20628955 | 0.86 | HDAC6 (0.47) | HDAC6HDAC1HDAC2HDAC8HDAC10 | |
| Hydrochloric Acid SCHEMBL20605300 | 0.85 | HDAC6 (0.46) | HDAC6HDAC1HDAC2HDAC8HDAC10 | |
| SCHEMBL24012219 | 0.83 | HDAC6 (0.51) | HDAC6HDAC1HDAC2HDAC8HDAC10 | |
| SCHEMBL28466018 | 0.81 | CHRM2 (0.48) | HDAC6HDAC1TBXA2RPTGDR | |
| SCHEMBL19162216 | 0.77 | HDAC6 (0.73) | HDAC6HDAC1HDAC2HDAC8TBXA2R | |
| SCHEMBL20605426 | 0.77 | HDAC6 (0.56) | HDAC6HDAC1HDAC2HDAC8HDAC10 | |
| SCHEMBL20634793 | 0.76 | HDAC6 (0.43) | HDAC6HDAC1HDAC2HDAC8TBXA2R | |
| SCHEMBL20605349 | 0.76 | HDAC6 (0.44) | HDAC6HDAC1HDAC2HDAC8SIRT2 | |
| Hydrochloric Acid SCHEMBL20610207 | 0.72 | HDAC6 (0.43) | HDAC6HDAC1HDAC2HDAC8HDAC10 | |
| SCHEMBL8381134 | 0.71 | HDAC6 (0.50) | HDAC6HDAC1HDAC2HDAC8TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019007836-A1 | NOVEL HDAC6 INHIBITORS, WITH IMPROVED SOLUBILITY AND THEIR USES | UNIVERSITÄT REGENSBURG (DE) | 2019-01-10 | — | — | WO | disclosed |