Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 18/20 | 0.74 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.71 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.71 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.67 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | CLK1 | P49759 | 1/20 | 0.64 |
| ▸ | IKBKB | O14920 | 2/20 | 0.60 |
| ▸ | CHUK | O15111 | 2/20 | 0.60 |
| ▸ | ABL1 | P00519 | 2/20 | 0.60 |
| ▸ | INSR | P06213 | 2/20 | 0.60 |
| ▸ | CDK2 | P24941 | 2/20 | 0.60 |
| ▸ | FLT3 | P36888 | 2/20 | 0.60 |
| ▸ | SGK1 | O00141 | 1/20 | 0.60 |
| ▸ | AURKA | O14965 | 1/20 | 0.60 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.60 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL723789 | 0.86 | MAP3K11 (1.00) | MAP3K11DYRK1ADYRK2DYRK1BCYP3A4 | |
| SCHEMBL721629 | 0.84 | MAP3K11 (1.00) | MAP3K11DYRK1ADYRK2DYRK1BCYP3A4 | |
| SCHEMBL723792 | 0.83 | MAP3K11 (0.71) | MAP3K11DYRK1ADYRK2DYRK1BCYP3A4 | |
| SCHEMBL722074 | 0.83 | MAP3K11 (0.71) | MAP3K11DYRK1ADYRK2DYRK1BCYP3A4 | |
| SCHEMBL12763475 | 0.83 | MAP3K11 (0.83) | MAP3K11DYRK1ADYRK2DYRK1BCYP3A4 | |
| SCHEMBL724304 | 0.83 | MAP3K11 (0.83) | MAP3K11DYRK1ADYRK2DYRK1BCYP3A4 | |
| SCHEMBL722261 | 0.81 | MAP3K11 (0.80) | MAP3K11DYRK1ADYRK2DYRK1BCYP3A4 | |
| SCHEMBL720976 | 0.81 | MAP3K11 (1.00) | MAP3K11DYRK1ADYRK2DYRK1BCYP3A4 | |
| SCHEMBL17226871 | 0.80 | MAP3K11 (0.81) | MAP3K11DYRK1ADYRK2DYRK1BCYP3A4 | |
| SCHEMBL723923 | 0.80 | MAP3K11 (1.00) | MAP3K11DYRK1ADYRK2DYRK1BCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2925319-B1 | MIXED LINEAGE KINASE INHIBITORS FOR HIV/AIDS THERAPIES | UNIV ROCHESTER (US) | 2019-01-09 | — | — | EP | disclosed |