Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.74 |
| ▸ | IGF1R | P08069 | 2/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | NSD2 | O96028 | 1/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.74 |
| ▸ | GAA | P10253 | 1/20 | 0.74 |
| ▸ | MAPT | P10636 | 1/20 | 0.74 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.74 |
| ▸ | RECQL | P46063 | 1/20 | 0.74 |
| ▸ | GFER | P55789 | 1/20 | 0.74 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.74 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 9/20 | 0.62 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.62 |
| ▸ | GSK3B | P49841 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | NAT1 | P18440 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19119969 | 1.00 | TDP1 (0.74) | TDP1IGF1RKDM4ENSD2POLB | |
| SCHEMBL1249001 | 0.85 | IGF1R (1.00) | TDP1IGF1RKDM4ENSD2POLB | |
| SCHEMBL15421303 | 0.85 | TDP1 (1.00) | TDP1IGF1RKDM4ENSD2POLB | |
| SCHEMBL15421307 | 0.85 | TDP1 (1.00) | TDP1IGF1RKDM4ENSD2POLB | |
| SCHEMBL30990562 | 0.85 | IGF1R (1.00) | TDP1IGF1RKDM4ENSD2POLB | |
| SCHEMBL1249000 | 0.85 | IGF1R (1.00) | TDP1IGF1RKDM4ENSD2POLB | |
| SCHEMBL15421305 | 0.85 | TDP1 (1.00) | TDP1IGF1RKDM4ENSD2POLB | |
| SCHEMBL1250908 | 0.79 | PTPN1 (1.00) | TDP1IGF1RKDM4ENSD2POLB | |
| SCHEMBL1250906 | 0.79 | PTPN1 (1.00) | TDP1IGF1RKDM4ENSD2POLB | |
| SCHEMBL1247522 | 0.78 | PIM1 (0.72) | IGF1RPOLBHPGDAKR1B1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10787425-B2 | Thiazolidinedione derivative and use thereof | INDUSTRY-ACADEMIC COOPERATION FOUNDATION CHOSUN UNIVERSITY (KR) | 2020-09-29 | — | — | US | disclosed |
| US-20190016695-A1 | THIAZOLIDINEDIONE DERIVATIVE AND USE THEREOF | INDUSTRY-ACADEMIC COOPERATION FOUNDATION CHOSUN UNIVERSITY (KR) | 2019-01-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190016695-A1 | THIAZOLIDINEDIONE DERIVATIVE AND USE THEREOF | PPARD, SLC5A2, SLC5A1 | TDP1 4537/4885IGF1R 500/4885KDM4E 2924/4885 |
| US-10787425-B2 | Thiazolidinedione derivative and use thereof | PPARD, SLC5A2, SLC5A1 | TDP1 4537/4885IGF1R 500/4885KDM4E 2924/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.