SCHEMBL20637781

SCHEMBL20637781

COc1ccc(C(OC[C@H]2O[C@@H](n3cnc4c(N)ncnc43)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]2NCc2ccccc2)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.50

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ ADORA1 P30542 2/20 0.50
▸ TYMP P19971 6/20 0.49
▸ CARM1 Q86X55 2/20 0.45
▸ NT5E P21589 1/20 0.43
▸ DOT1L Q8TEK3 1/20 0.41
▸ AHCY P23526 1/20 0.40
▸ TRDMT1 O14717 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28827070 0.90 ADORA1 (0.51) ADORA1TYMPCARM1NT5ETRDMT1
SCHEMBL19127994 0.88 TYMP (0.59) ADORA1TYMPCARM1NT5EDOT1L
SCHEMBL31670489 0.88 TYMP (0.59) ADORA1TYMPCARM1NT5EDOT1L
SCHEMBL21979489 0.86 TYMP (0.53) TYMPNT5E
SCHEMBL19128529 0.86 TYMP (0.53) TYMPNT5E
SCHEMBL7210212 0.84 ADORA1 (0.52) ADORA1TYMPCARM1NT5ETRDMT1
SCHEMBL19146234 0.84 ADORA1 (0.51) ADORA1DOT1LAHCY
SCHEMBL29832246 0.83 ADORA1 (0.49) ADORA1TYMPCARM1NT5ETRDMT1
SCHEMBL19127764 0.83 ADORA1 (0.49) ADORA1TYMPCARM1NT5ETRDMT1
SCHEMBL18042131 0.80 ADORA1 (0.64) ADORA1TYMPNT5ETRDMT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3402801-B1 CYCLIC DINUCLEOTIDES FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY SUCH AS CANCER INNATE TUMOR IMMUNITY INC (US) 2025-08-06 — — EP disclosed
US-11505571-B2 Compounds and compositions for treating conditions associated with sting activity INNATE TUMOR IMMUNITY, INC. (US) 2022-11-22 — — US disclosed
US-20210147467-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY INNATE TUMOR IMMUNITY INC (US) 2021-05-20 — — US disclosed
US-10961270-B2 Compounds and compositions for treating conditions associated with sting activity INNATE TUMOR IMMUNITY, INC. (US) 2021-03-30 — — US disclosed
US-20200165288-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY INNATE TUMOR IMMUNITY INC (US) 2020-05-28 — — US disclosed
US-10604542-B2 Cyclic dinucleotides for treating conditions associated with sting activity such as cancer INNATE TUMOR IMMUNITY, INC. (US) 2020-03-31 — — US disclosed
US-20190016750-A1 CYCLIC DINUCLEOTIDES FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY SUCH AS CANCER Innate Tumoir Immunity, Inc. (US) 2019-01-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10961270-B2 Compounds and compositions for treating conditions associated with sting activity STING1, CGAS, IRF3 ADORA1 842/4885TYMP 2613/4885CARM1 2608/4885
US-20200165288-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY STING1, CGAS, IRF3 ADORA1 842/4885TYMP 2613/4885CARM1 2608/4885
US-11505571-B2 Compounds and compositions for treating conditions associated with sting activity STING1, CGAS, IRF3 ADORA1 842/4885TYMP 2613/4885CARM1 2608/4885
US-10604542-B2 Cyclic dinucleotides for treating conditions associated with sting activity such as cancer STING1, CGAS, IRF3 ADORA1 1007/4885TYMP 112/4885CARM1 2216/4885
US-20190016750-A1 CYCLIC DINUCLEOTIDES FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY SUCH AS CANCER STING1, CGAS, IRF3 ADORA1 1007/4885TYMP 112/4885CARM1 2216/4885
US-20210147467-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY STING1, CGAS, IRF3 ADORA1 842/4885TYMP 2613/4885CARM1 2608/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback