Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 10/20 | 1.00 |
| ▸ | SLCO1B3 | Q9NPD5 | 8/20 | 1.00 |
| ▸ | SLCO1B1 | Q9Y6L6 | 8/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 1.00 |
| ▸ | TP53 | P04637 | 4/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | USP2 | O75604 | 6/20 | 0.76 |
| ▸ | MAPT | P10636 | 4/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.76 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | MIF | P14174 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9973669 | 1.00 | CYP3A4 (1.00) | CYP3A4SLCO1B3SLCO1B1SMN1; SMN2TP53 | |
| SCHEMBL14197006 | 1.00 | CYP3A4 (1.00) | CYP3A4SLCO1B3SLCO1B1SMN1; SMN2TP53 | |
| SCHEMBL17616912 | 1.00 | CYP3A4 (1.00) | CYP3A4SLCO1B3SLCO1B1SMN1; SMN2TP53 | |
| SCHEMBL10019478 | 1.00 | CYP3A4 (1.00) | CYP3A4SLCO1B3SLCO1B1SMN1; SMN2TP53 | |
| SCHEMBL598727 | 1.00 | CYP3A4 (1.00) | CYP3A4SLCO1B3SLCO1B1SMN1; SMN2TP53 | |
| SCHEMBL9973671 | 0.92 | CYP3A4 (0.85) | CYP3A4SLCO1B3SLCO1B1SMN1; SMN2TP53 | |
| SCHEMBL10019477 | 0.87 | CYP3A4 (0.77) | CYP3A4SLCO1B3SLCO1B1SMN1; SMN2TP53 | |
| SCHEMBL9973651 | 0.87 | CYP3A4 (0.77) | CYP3A4SLCO1B3SLCO1B1SMN1; SMN2TP53 | |
| Azadiradione SCHEMBL19588462 | 0.87 | CYP3A4 (0.77) | CYP3A4SLCO1B3SLCO1B1SMN1; SMN2TP53 | |
| Azadiradione SCHEMBL29398035 | 0.87 | CYP3A4 (0.77) | CYP3A4SLCO1B3SLCO1B1SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190015423-A1 | REGULATION OF GENE EXPRESSION BY MODULATING PRIMARY CILIA LENGTH | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-01-17 | — | — | US | claimed |
| US-20190015423-A1 | REGULATION OF GENE EXPRESSION BY MODULATING PRIMARY CILIA LENGTH | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-01-17 | — | — | US | disclosed |