⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1382368 | 0.95 | POLB (0.32) | — | |
| SCHEMBL105607 | 0.93 | POLB (0.35) | — | |
| SCHEMBL22422290 | 0.93 | POLB (0.35) | — | |
| Hydrochloric Acid SCHEMBL19126647 | 0.91 | POLB (0.34) | — | |
| SCHEMBL2516568 | 0.90 | — | — | |
| Hydrochloric Acid SCHEMBL2173120 | 0.89 | POLB (0.33) | — | |
| SCHEMBL340232 | 0.81 | NEK2 (0.38) | — | |
| SCHEMBL19094306 | 0.81 | HSD11B1 (0.30) | — | |
| SCHEMBL24535221 | 0.81 | — | — | |
| SCHEMBL24537298 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11365205-B2 | Imidazolidin-2-one compounds as PRMT5 modulators | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2022-06-21 | — | — | US | claimed |
| US-10738015-B2 | 1,3-diaza-spiro-[3.4]-octane derivatives | Grünenthal GmbH (DE) | 2020-08-11 | — | — | US | claimed |
| EP-3652157-A1 | 1,3-DIAZA-SPIRO-[3.4]-OCTANE DERIVATIVES | Grünenthal GmbH (DE) | 2020-05-20 | — | — | EP | claimed |
| WO-2019012037-A1 | 1,3-DIAZA-SPIRO-[3.4]-OCTANE DERIVATIVES | Grünenthal GmbH (DE) | 2019-01-17 | — | — | WO | claimed |
| US-20220324878-A1 | IMIDAZOLIDIN-2-ONE COMPOUNDS AS PRMT5 MODULATORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2022-10-13 | — | — | US | disclosed |
| US-11365205-B2 | Imidazolidin-2-one compounds as PRMT5 modulators | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2022-06-21 | — | — | US | disclosed |
| US-20220009918-A1 | Chemical Compounds | GLAXOSMITHKLINE IP DEV LTD (GB) | 2022-01-13 | — | — | US | disclosed |
| US-10738015-B2 | 1,3-diaza-spiro-[3.4]-octane derivatives | Grünenthal GmbH (DE) | 2020-08-11 | — | — | US | disclosed |
| EP-3652157-A1 | 1,3-DIAZA-SPIRO-[3.4]-OCTANE DERIVATIVES | Grünenthal GmbH (DE) | 2020-05-20 | — | — | EP | disclosed |
| US-20190134005-A1 | CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE | BIOMARIN PHARM INC (US) | 2019-05-09 | — | — | US | disclosed |
| WO-2019012037-A1 | 1,3-DIAZA-SPIRO-[3.4]-OCTANE DERIVATIVES | Grünenthal GmbH (DE) | 2019-01-17 | — | — | WO | disclosed |