Sugi Predict

Sugi Predict / Compounds / SCHEMBL20642945

SCHEMBL20642945

SCHEMBL20642945

C=C1C(=O)O[C@H]2c3c(C)c(OCc4ccccc4C)cc(C)c3CC[C@@H]12

nearest known ligand 0.85

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ UBE2D3 P61077 1/20 0.85
▸ CDK4 P11802 1/20 0.35
▸ CCND1 P24385 1/20 0.35
▸ ACHE P22303 1/20 0.35
▸ BRD4 O60885 1/20 0.33
▸ GPR84 Q9NQS5 1/20 0.33
▸ TRPM8 Q7Z2W7 2/20 0.32
▸ TAS2R46 P59540 2/20 0.32
▸ MAOB P27338 2/20 0.32
▸ MEN1 O00255 1/20 0.32
▸ RECQL P46063 1/20 0.32
▸ KMT2A Q03164 1/20 0.32
▸ TDP1 Q9NUW8 1/20 0.32
▸ TERT O14746 1/20 0.32
▸ PKM P14618 1/20 0.32
▸ SGMS2 Q8NHU3 1/20 0.31
▸ ADRA2A P08913 1/20 0.31
▸ ADRA2B P18089 1/20 0.31
▸ ADRA2C P18825 1/20 0.31
▸ PSEN1 P49768 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20642938 0.94 UBE2D3 (0.79) UBE2D3BRD4TAS2R46MEN1RECQL
SCHEMBL22154757 0.94 UBE2D3 (0.79) UBE2D3BRD4TAS2R46MEN1RECQL
SCHEMBL20642947 0.92 UBE2D3 (0.79) UBE2D3MAOBMEN1KMT2ATDP1
SCHEMBL21951134 0.92 UBE2D3 (1.00) UBE2D3BRD4MAOB
SCHEMBL22155345 0.92 UBE2D3 (0.79) UBE2D3MEN1RECQLKMT2ATDP1
SCHEMBL20642952 0.92 UBE2D3 (0.79) UBE2D3
SCHEMBL22155350 0.92 UBE2D3 (0.79) UBE2D3
SCHEMBL20642993 0.92 UBE2D3 (0.79) UBE2D3GPR84MEN1KMT2ATDP1
SCHEMBL20642994 0.92 UBE2D3 (1.00) UBE2D3BRD4MAOB
SCHEMBL22155109 0.92 UBE2D3 (0.79) UBE2D3GPR84MEN1KMT2ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3653614-B1 TETRAHYDRONAPHTHO[1,2-B]FURAN-2(3H)-ONE DERIVATIVE AND PREPARATION AND USE THEREOF IN PHARMACEUTICALS SHANGHAI QINGDONG BIOTECHNOLOGY CO LTD (CN) 2022-04-20 — — EP disclosed
US-11034663-B2 Tetrahydronaphtho[1,2-b]furan-2(3H)-one derivatives and preparation and uses thereof Shanghai Qingdong Biotechnology Co., Ltd (CN) 2021-06-15 — — US disclosed
US-20200199089-A1 TETRAHYDRONAPHTHO[1,2-B]FURAN-2(3H)-ONE DERIVATIVES AND PREPARATION AND USES THEREOF Shanghai Qingdong Biotechnology Co., Ltd. (CN) 2020-06-25 — — US disclosed
WO-2019011285-A1 TETRAHYDRONAPHTHO[1,2-B]FURAN-2(3H)-ONE DERIVATIVE AND PREPARATION AND USE THEREOF IN PHARMACEUTICALS 孙青� 2019-01-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200199089-A1 TETRAHYDRONAPHTHO[1,2-B]FURAN-2(3H)-ONE DERIVATIVES AND PREPARATION AND USES THEREOF NR0B1, FOXM1, CYP1A1 UBE2D3 2113/4885CDK4 1563/4885CCND1 274/4885
US-11034663-B2 Tetrahydronaphtho[1,2-b]furan-2(3H)-one derivatives and preparation and uses thereof NR0B1, FOXM1, CYP1A1 UBE2D3 2113/4885CDK4 1563/4885CCND1 274/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.