Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.71 |
| ▸ | RAB9A | P51151 | 4/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.68 |
| ▸ | MAPT | P10636 | 6/20 | 0.68 |
| ▸ | TP53 | P04637 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.68 |
| ▸ | HPGD | P15428 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | CASP1 | P29466 | 1/20 | 0.68 |
| ▸ | CASP7 | P55210 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | GFER | P55789 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12799147 | 1.00 | NPC1 (0.71) | NPC1RAB9AALDH1A1MAPTTP53 | |
| Hydrochloric Acid SCHEMBL2159983 | 0.98 | NPC1 (0.69) | NPC1RAB9AALDH1A1MAPTTP53 | |
| SCHEMBL1821338 | 0.97 | ALDH1A1 (0.70) | NPC1RAB9AALDH1A1MAPTTP53 | |
| Hydrochloric Acid SCHEMBL22031645 | 0.95 | MAPT (0.68) | NPC1RAB9AALDH1A1MAPTTP53 | |
| SCHEMBL5760520 | 0.93 | NPC1 (0.65) | NPC1RAB9AALDH1A1MAPTTP53 | |
| SCHEMBL16404482 | 0.92 | MAPT (0.64) | NPC1RAB9AALDH1A1MAPTTP53 | |
| SCHEMBL8577561 | 0.88 | NPC1 (0.59) | NPC1RAB9AALDH1A1MAPTTP53 | |
| SCHEMBL10373626 | 0.87 | MAPT (0.77) | NPC1RAB9AALDH1A1MAPTTP53 | |
| SCHEMBL6887590 | 0.87 | ALDH1A1 (0.71) | NPC1RAB9AALDH1A1MAPTTP53 | |
| SCHEMBL22495739 | 0.86 | MAPT (0.69) | NPC1RAB9AALDH1A1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 102 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107428730-A | New 1,3,5 triazine radical PI3K inhibitor as antitumor and anticancer agent and preparation method thereof | 科学与工业研究会 | 2017-12-01 | — | — | CN | claimed |
| CN-106452100-A | Three-level photovoltaic grid-connected inverter based on DSP control and working method of three-level photovoltaic grid-connected inverter | 江苏建筑职业技术学院 | 2017-02-22 | — | — | CN | claimed |
| CN-102239146-A | Novel compounds as calcium channel blockers | ABBOTT LAB | 2011-11-09 | — | — | CN | claimed |
| CN-1440390-A | Substituted diamine derivatives as motilin antagonists | ORTHO MCNEIL PHARM INC (US) | 2003-09-03 | — | — | CN | claimed |
| EP-1294695-A2 | SUBSTITUTED DIAMIDE DERIVATIVES USEFUL AS MOTILIN ANTAGONISTS | Ortho-McNeil Pharmaceutical, Inc. (US) | 2003-03-26 | — | — | EP | claimed |
| WO-2001085694-A2 | SUBSTITUTED DIAMIDE DERIVATIVES USEFUL AS MOTILIN ANTAGONISTS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-11-15 | — | — | WO | claimed |
| EP-0846676-B1 | Process for the preparation of aromatic amines from aryl chlorides | AXIVA GMBH (DE) | 2001-02-07 | — | — | EP | claimed |
| CN-117756747-A | Preparation method of N-phenyl nitrogen-containing polycyclic quaternary ammonium salt compound | 济宁医学院 | 2024-03-26 | — | — | CN | disclosed |
| EP-4126840-A1 | ARYL PIPERIDINES AS MONOACYLGLYCEROL LIPASE MODULATORS | Janssen Pharmaceutica NV (BE) | 2023-02-08 | — | — | EP | disclosed |
| EP-3459948-B1 | FLUORINE-CONTAINING TRIAZOLOPYRIDINE, AND MANUFACTURING METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2021-11-17 | — | — | EP | disclosed |
| EP-3371196-B1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF PLATELET AGGREGATION | UNIV MONTREAL (CA) | 2021-10-27 | — | — | EP | disclosed |
| CN-107383002-B | Fluorine-containing triazole pyridine compounds, and preparation method, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2021-07-13 | — | — | CN | disclosed |
| US-10800776-B2 | Fluorine-containing triazolopyridine, and manufacturing method, pharmaceutical composition, and application thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2020-10-13 | — | — | US | disclosed |
| CN-1261366-A | Azothiazine compounds and pyrrolethiazepine compounds having 5-hydroxytryptamine-2-receptor antagonistic and alpha-1-blocking effects | SUNTORY LTD (JP) | 2000-07-26 | — | — | CN | disclosed |
| CN-1260798-A | Has 5-hydroxytryptamine-2 receptor antagonistic effect and alpha1Azothiazine and pyrrolethiazepine compounds with blocking action | SUNTORY LTD (JP) | 2000-07-19 | — | — | CN | disclosed |
| CN-1219173-A | Pyrroloazepine compounds | SUNTORY LTD (JP) | 1999-06-09 | — | — | CN | disclosed |
| US-5831128-A | Synthesis of aromatic amines from chloroamatics | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-11-03 | — | — | US | disclosed |
| EP-0846676-A1 | Process for the preparation of aromatic amines from aryl chlorides | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-06-10 | — | — | EP | disclosed |
| US-5554383-A | ADMINISTERING SELECTIVE SEROTONIN REUPTAKE INHIBITOR | TRUSTEES OF TUFTS COLLEGE (US) | 1996-09-10 | — | — | US | disclosed |
| CN-1119859-A | benzothiazine derivatives | SUNTORY LTD (JP) | 1996-04-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10800776-B2 | Fluorine-containing triazolopyridine, and manufacturing method, pharmaceutical composition, and application thereof | GRM2, GRM1, GRIK2 | NPC1 2063/4885RAB9A 1656/4885ALDH1A1 3621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.