Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | MGAM | O43451 | 1/20 | 0.49 |
| ▸ | SI | P14410 | 1/20 | 0.49 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 10/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26759054 | 0.76 | GAA (0.46) | GAAMGAMSIMGAM2APP | |
| SCHEMBL20641452 | 0.76 | LMNA (0.46) | SNCAMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL22466129 | 0.76 | SNCA (0.56) | SNCAGAAMGAMSIMGAM2 | |
| SCHEMBL14157145 | 0.76 | SNCA (0.66) | SNCAGAAMGAMSIMGAM2 | |
| SCHEMBL15090524 | 0.76 | SNCA (0.56) | SNCAMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL25382795 | 0.76 | SNCA (0.56) | SNCAAPPMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL20641446 | 0.76 | SNCA (0.56) | SNCAGAAAPPMAPTSMN1; SMN2 | |
| SCHEMBL1181322 | 0.75 | SNCA (0.51) | SNCAAPPMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL928439 | 0.75 | SNCA (0.55) | SNCAMAPTSMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL1849553 | 0.75 | GAA (0.45) | GAAMGAMSIMGAM2APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3652159-B1 | SUBSTITUTED THIAZOLE DERIVATIVES AS RAD51 INHIBITORS FOR THE TREATMENT OF CANCER DISEASES, AUTOIMMUNE AND NEURODEGENERATIVE CONDITIONS | CYTEIR THERAPEUTICS INC (US) | 2023-01-18 | — | — | EP | disclosed |
| WO-2019014315-A1 | RAD51 INHIBITORS | CYTEIR THERAPEUTICS, INC. (US) | 2019-01-17 | — | — | WO | disclosed |