Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Misoprostol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER3 known ✓ | P43115 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 2/20 | 1.00 |
| ▸ | PGR | P06401 | 2/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 1.00 |
| ▸ | POLB | P06746 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 1/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | PTGIR | P43119 | 9/20 | 0.61 |
| ▸ | PTGER2 | P43116 | 8/20 | 0.61 |
| ▸ | PTGER4 | P35408 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.49 |
| ▸ | RARB | P10826 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13400599 | 1.00 | LMNA (1.00) | LMNAABCC4PGRALDH1A1POLB | |
| Misoprostol SCHEMBL3669679 | 1.00 | LMNA (1.00) | LMNAABCC4PGRALDH1A1POLB | |
| Misoprostol SCHEMBL22039860 | 1.00 | LMNA (1.00) | LMNAABCC4PGRALDH1A1POLB | |
| Misoprostol SCHEMBL22381095 | 1.00 | LMNA (1.00) | LMNAABCC4PGRALDH1A1POLB | |
| Misoprostol SCHEMBL24176879 | 1.00 | LMNA (1.00) | LMNAABCC4PGRALDH1A1POLB | |
| Misoprostol SCHEMBL24176880 | 1.00 | LMNA (1.00) | LMNAABCC4PGRALDH1A1POLB | |
| Misoprostol SCHEMBL22381098 | 1.00 | LMNA (1.00) | LMNAABCC4PGRALDH1A1POLB | |
| Misoprostol SCHEMBL23352527 | 1.00 | LMNA (1.00) | LMNAABCC4PGRALDH1A1POLB | |
| Misoprostol SCHEMBL21423327 | 1.00 | LMNA (1.00) | LMNAABCC4PGRALDH1A1POLB | |
| SCHEMBL14071594 | 1.00 | LMNA (1.00) | LMNAABCC4PGRALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019011668-A1 | PROCESS FOR THE PREPARATION AND PURIFICATION OF MISOPROSTOL | CHINOIN PHARMACEUTICAL AND CHEMICAL WORKS PRIVATE CO. LTD. (HU) | 2019-01-17 | — | — | WO | disclosed |