Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | IDH1 | O75874 | 3/20 | 0.41 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2064441 | 1.00 | GLS (0.43) | GLSNPC1LMNATP53HPGD | |
| SCHEMBL5242251 | 0.87 | GLS (0.46) | GLSNPC1LMNATP53HPGD | |
| SCHEMBL13104615 | 0.87 | GLS (0.46) | GLSNPC1LMNATP53HPGD | |
| SCHEMBL2065214 | 0.86 | IDH1 (0.41) | GLSNPC1LMNATP53HPGD | |
| SCHEMBL266818 | 0.82 | GLS (0.46) | GLSNPC1LMNATP53HPGD | |
| SCHEMBL17870942 | 0.82 | GLS (0.46) | GLSNPC1LMNATP53HPGD | |
| SCHEMBL12333636 | 0.82 | GLS (0.46) | GLSNPC1LMNATP53HPGD | |
| SCHEMBL8138150 | 0.82 | HDAC1 (0.44) | GLSNPC1LMNATP53HPGD | |
| SCHEMBL5890288 | 0.82 | AVPR1A (0.45) | GLSSMN1; SMN2HDAC1ALDH1A1 | |
| SCHEMBL6948748 | 0.82 | GLS (0.42) | GLSNPC1LMNATP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120295329-A1 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES SHOW IMPROVED CATALYTIC ACTIVITY AND CHIRAL SELECTIVITY | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2012-11-22 | — | — | US | claimed |
| US-20120156721-A1 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES SHOW IMPROVED CATALYTIC ACTIVITY AND CHIRAL SELECTIVITY | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2012-06-21 | — | — | US | claimed |
| US-20090075329-A1 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES SHOW IMPROVED CATALYTIC ACTIVITY AND CHIRAL SELECTIVITY | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2009-03-19 | — | — | US | claimed |
| US-20050282248-A1 | Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity | JONES JOHN B | 2005-12-22 | — | — | US | claimed |
| EP-1129180-A2 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES | GENENCOR INTERNATIONAL, INC. (US) | 2001-09-05 | — | — | EP | claimed |
| WO-2000028007-A2 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES | GENENCOR INTERNATIONAL, INC. (US) | 2000-05-18 | — | — | WO | claimed |
| US-8357524-B2 | Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity | DANISCO US INC. (US) | 2013-01-22 | — | — | US | disclosed |
| US-20120295329-A1 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES SHOW IMPROVED CATALYTIC ACTIVITY AND CHIRAL SELECTIVITY | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2012-11-22 | — | — | US | disclosed |
| US-20120156721-A1 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES SHOW IMPROVED CATALYTIC ACTIVITY AND CHIRAL SELECTIVITY | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2012-06-21 | — | — | US | disclosed |
| US-8148128-B2 | Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2012-04-03 | — | — | US | disclosed |
| US-20090075329-A1 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES SHOW IMPROVED CATALYTIC ACTIVITY AND CHIRAL SELECTIVITY | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2009-03-19 | — | — | US | disclosed |
| US-20050282248-A1 | Chemically modified mutant serine hydrolases show improved catalytic activity and chiral selectivity | JONES JOHN B | 2005-12-22 | — | — | US | disclosed |
| EP-1129180-A2 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES | GENENCOR INTERNATIONAL, INC. (US) | 2001-09-05 | — | — | EP | disclosed |
| WO-2000028007-A2 | CHEMICALLY MODIFIED MUTANT SERINE HYDROLASES | GENENCOR INTERNATIONAL, INC. (US) | 2000-05-18 | — | — | WO | disclosed |