Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.58 |
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20638639 | 0.88 | SCN8A (0.56) | SCN8ASCN10A | |
| SCHEMBL16398455 | 0.87 | — | — | |
| SCHEMBL30535928 | 0.87 | — | — | |
| SCHEMBL19563666 | 0.86 | SCN8A (0.53) | SCN8ASCN10A | |
| SCHEMBL20644043 | 0.81 | SCN8A (0.54) | SCN8ASCN10A | |
| SCHEMBL31297308 | 0.81 | SCN8A (0.54) | SCN8ASCN10A | |
| SCHEMBL16408283 | 0.79 | — | — | |
| SCHEMBL30853207 | 0.79 | SCN8A (0.69) | SCN8ASCN10A | |
| SCHEMBL29179819 | 0.79 | SCN8A (0.69) | SCN8ASCN10A | |
| SCHEMBL17791084 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019014352-A1 | CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2019-01-17 | — | — | WO | disclosed |