Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17454370 | 0.88 | ROCK2 (0.55) | ROCK2 | |
| SCHEMBL17437880 | 0.88 | ROCK2 (0.54) | ROCK2 | |
| SCHEMBL19151443 | 0.87 | ROCK2 (0.61) | ROCK2 | |
| SCHEMBL23587195 | 0.86 | ROCK2 (0.58) | ROCK2 | |
| SCHEMBL19902682 | 0.86 | ROCK2 (0.52) | ROCK2 | |
| SCHEMBL17452627 | 0.85 | ROCK2 (0.52) | ROCK2 | |
| SCHEMBL23683866 | 0.83 | ROCK2 (0.50) | ROCK2 | |
| SCHEMBL21948600 | 0.81 | ROCK2 (0.49) | ROCK2 | |
| SCHEMBL20654134 | 0.81 | ROCK2 (0.49) | ROCK2 | |
| SCHEMBL23587398 | 0.79 | ROCK2 (0.53) | ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019014308-A1 | 5-MEMBERED AND BICYCLIC HETEROCYCLIC AMIDES AS INHIBITORS OF ROCK | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-01-17 | — | — | WO | disclosed |