Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.47 |
| ▸ | DHODH | Q02127 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9352794 | 0.85 | MAPT (0.51) | MAPTGAATDP1CYP19A1DHODH | |
| SCHEMBL9352801 | 0.85 | MAPT (0.51) | MAPTGAATDP1CYP19A1DHODH | |
| SCHEMBL8581102 | 0.85 | MAPT (0.51) | MAPTGAATDP1CYP19A1DHODH | |
| SCHEMBL20001619 | 0.84 | MAPT (0.45) | MAPTGAATDP1CYP19A1DHODH | |
| SCHEMBL9750990 | 0.83 | MAPT (0.55) | MAPTGAATDP1CYP19A1DHODH | |
| SCHEMBL3631341 | 0.83 | MAPT (0.55) | MAPTGAATDP1CYP19A1DHODH | |
| SCHEMBL18743582 | 0.76 | GAA (0.48) | MAPTGAATDP1CYP19A1DHODH | |
| SCHEMBL18707907 | 0.75 | CYP19A1 (0.54) | MAPTGAATDP1CYP19A1ALDH1A1 | |
| SCHEMBL13381411 | 0.75 | ALDH1A1 (0.56) | MAPTGAATDP1CYP19A1ALDH1A1 | |
| SCHEMBL21028605 | 0.75 | NPSR1 (0.41) | MAPTGAADHODHALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970138-B1 | PYRAZOLE DERIVATIVES AND THEIR USES THEREOF | CANADIAN BLOOD SERVICES (CA) | 2019-01-16 | — | — | EP | disclosed |