SCHEMBL20656164

SCHEMBL20656164

CC(C)n1cnc2c(O)nc(F)nc21

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK2 P24941 10/20 0.49
CDK1 P06493 10/20 0.49
CCNB1 P14635 6/20 0.49
CCNE1 P24864 5/20 0.49
ADORA2A P29274 1/20 0.42
ADORA2B P29275 1/20 0.42
ADORA1 P30542 1/20 0.42
PI4KA P42356 1/20 0.42
PI4K2B Q8TCG2 1/20 0.42
PI4K2A Q9BTU6 1/20 0.42
PI4KB Q9UBF8 1/20 0.42
CDK5 Q00535 8/20 0.40
CDK5R1 Q15078 7/20 0.40
NPC1 O15118 3/20 0.40
POLB P06746 1/20 0.40
CCNA2 P20248 4/20 0.39
CCNA1 P78396 4/20 0.39
PRKACA P17612 1/20 0.39
PRKACG P22612 1/20 0.39
PRKACB P22694 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20656163 0.83 CDK1 (0.51) CDK2CDK1CCNB1CCNE1ADORA2A
SCHEMBL13057431 0.81 CDK1 (0.50) CDK2CDK1CCNB1CCNE1ADORA2A
SCHEMBL1293109 0.80 CDK2 (0.49) CDK2CDK1CCNB1CCNE1ADORA2A
SCHEMBL21540017 0.80 CDK1 (0.71) CDK2CDK1CCNB1CCNE1ADORA2A
SCHEMBL14039518 0.80 CDK1 (0.71) CDK2CDK1CCNB1CCNE1ADORA2A
SCHEMBL31707890 0.80 CDK2 (0.49) CDK2CDK1CCNB1CCNE1ADORA2A
SCHEMBL24181537 0.78 CDK2 (0.46) CDK2CDK1CCNB1CCNE1ADORA2A
SCHEMBL23027205 0.77 CDK1 (0.42) CDK2CDK1CCNB1CCNE1ADORA2A
SCHEMBL15046609 0.76 CDK2 (0.45) CDK2CDK1CCNB1CCNE1ADORA2A
SCHEMBL18751223 0.74 ADORA2A (0.64) CDK2CDK1CCNB1CCNE1ADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11576968-B2 Hepatitis C virus immunogenic compositions and methods of use thereof THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2023-02-14 US disclosed
US-20210170018-A1 HEPATITIS C VIRUS IMMUNOGENIC COMPOSITIONS AND METHODS OF USE THEREOF THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2021-06-10 US disclosed
US-10881726-B2 Hepatitis C virus immunogenic compositions and methods of use thereof THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2021-01-05 US disclosed
US-20190231867-A1 HEPATITIS C VIRUS IMMUNOGENIC COMPOSITIONS AND METHODS OF USE THEREOF THE GOVERNORS OF THE UNIVERSITY OF ALBERTA (CA) 2019-08-01 US disclosed
US-10357560-B2 Use of fluorinated cyclic dinucleotides as oral vaccine adjuvants BROCK UNIVERSITY (CA) 2019-07-23 US disclosed
US-20190015502-A1 USE OF FLUORINATED CYCLIC DINUCLEOTIDES AS ORAL VACCINE ADJUVANTS BROCK UNIVERSITY (CA) 2019-01-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210170018-A1 HEPATITIS C VIRUS IMMUNOGENIC COMPOSITIONS AND METHODS OF USE THEREOF HAVCR2, CD74, DNAJC10 CDK2 3360/4885CDK1 3695/4885CCNB1 2079/4885
US-10881726-B2 Hepatitis C virus immunogenic compositions and methods of use thereof HAVCR2, CD74, DNAJC10 CDK2 3360/4885CDK1 3695/4885CCNB1 2079/4885
US-20190231867-A1 HEPATITIS C VIRUS IMMUNOGENIC COMPOSITIONS AND METHODS OF USE THEREOF HAVCR2, CD74, DNAJC10 CDK2 3360/4885CDK1 3695/4885CCNB1 2079/4885
US-10357560-B2 Use of fluorinated cyclic dinucleotides as oral vaccine adjuvants TLR9, CGAS, DUT CDK2 4522/4885CDK1 4800/4885CCNB1 4043/4885
US-20190015502-A1 USE OF FLUORINATED CYCLIC DINUCLEOTIDES AS ORAL VACCINE ADJUVANTS TLR9, CGAS, DUT CDK2 4522/4885CDK1 4800/4885CCNB1 4043/4885
US-11576968-B2 Hepatitis C virus immunogenic compositions and methods of use thereof HAVCR2, CD74, DNAJC10 CDK2 3360/4885CDK1 3695/4885CCNB1 2079/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.