Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 4/20 | 0.38 |
| ▸ | CCND1 | P24385 | 4/20 | 0.38 |
| ▸ | SCD | O00767 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19691088 | 0.84 | DRD2 (0.55) | DRD2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL30364138 | 0.84 | DRD2 (0.55) | DRD2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL12534041 | 0.81 | DRD2 (0.49) | DRD2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL29423860 | 0.80 | DRD2 (0.63) | DRD2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL367111 | 0.80 | DRD2 (0.63) | DRD2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL24109904 | 0.77 | DRD2 (0.49) | DRD2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL12605572 | 0.77 | DRD2 (0.59) | DRD2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL3640167 | 0.77 | DRD2 (0.59) | DRD2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL2424591 | 0.76 | DRD2 (0.58) | DRD2SLC6A4OPRM1OPRD1OPRK1 | |
| SCHEMBL31091985 | 0.76 | DRD2 (0.50) | DRD2SLC6A4OPRM1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190022071-A1 | METHODS OF TREATING PULMONARY DISEASES AND DISORDERS | PROTEOSTASIS THERAPEUTICS, INC. | 2019-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190022071-A1 | METHODS OF TREATING PULMONARY DISEASES AND DISORDERS | SMPD1, ELANE, SMPD2 | DRD2 2728/4885SLC6A4 1603/4885OPRM1 1556/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.