Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADCY8 | P40145 | 7/20 | 0.60 |
| ▸ | ADCY1 | Q08828 | 7/20 | 0.60 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20673082 | 0.84 | KDM4E (0.59) | ADCY8ADCY1POLBALDH1A1KDM4E | |
| SCHEMBL20673080 | 0.81 | NPSR1 (0.61) | ADCY8ADCY1POLBMAPTSMN1; SMN2 | |
| SCHEMBL20673009 | 0.81 | ADCY1 (0.73) | ADCY8ADCY1HTR2BSLC2A1 | |
| SCHEMBL20673130 | 0.80 | ADCY1 (0.59) | ADCY8ADCY1ALDH1A1KDM4EHTR2B | |
| SCHEMBL20673084 | 0.79 | SLC2A1 (0.54) | ADCY8ADCY1POLBMAPTSMN1; SMN2 | |
| SCHEMBL20673083 | 0.79 | ADCY1 (0.49) | ADCY8ADCY1POLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL20673058 | 0.79 | ADCY1 (0.80) | ADCY8ADCY1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL20673089 | 0.78 | ADCY1 (0.72) | ADCY8ADCY1HTR2B | |
| SCHEMBL20657976 | 0.78 | ADCY1 (0.69) | ADCY8ADCY1POLBMAPTSMN1; SMN2 | |
| SCHEMBL23160929 | 0.75 | ADCY1 (0.73) | ADCY8ADCY1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11667623-B2 | Scaffold of adenylyl cyclase inhibitors for chronic pain and opioid dependence | PURDUE RESEARCH FOUNDATION (US) | 2023-06-06 | — | — | US | disclosed |
| US-11667623-B2 | Scaffold of adenylyl cyclase inhibitors for chronic pain and opioid dependence | PURDUE RESEARCH FOUNDATION (US) | 2023-06-06 | — | — | US | disclosed |
| US-20200239447-A1 | NOVEL SCAFFOLD OF ADENYLYL CYCLASE INHIBITORS FOR CHRONIC PAIN AND OPIOID DEPENDENCE | PURDUE RESEARCH FOUNDATION (US) | 2020-07-30 | — | — | US | disclosed |
| US-10662176-B2 | Scaffold of adenylyl cyclase inhibitors for chronic pain and opioid dependence | PURDUE RESEARCH FOUNDATION (US) | 2020-05-26 | — | — | US | disclosed |
| US-20190023688-A1 | NOVEL SCAFFOLD OF ADENYLYL CYCLASE INHIBITORS FOR CHRONIC PAIN AND OPIOID DEPENDENCE | PURDUE RESEARCH FOUNDATION (US) | 2019-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200239447-A1 | NOVEL SCAFFOLD OF ADENYLYL CYCLASE INHIBITORS FOR CHRONIC PAIN AND OPIOID DEPENDENCE | CAP1, ADCY1, ADCYAP1R1 | ADCY8 7/4885ADCY1 2/4885POLB 4643/4885 |
| US-20190023688-A1 | NOVEL SCAFFOLD OF ADENYLYL CYCLASE INHIBITORS FOR CHRONIC PAIN AND OPIOID DEPENDENCE | CAP1, ADCY1, ADCYAP1R1 | ADCY8 7/4885ADCY1 2/4885POLB 4643/4885 |
| US-11667623-B2 | Scaffold of adenylyl cyclase inhibitors for chronic pain and opioid dependence | CAP1, ADCY1, ADCYAP1R1 | ADCY8 11/4885ADCY1 2/4885POLB 4587/4885 |
| US-10662176-B2 | Scaffold of adenylyl cyclase inhibitors for chronic pain and opioid dependence | CAP1, ADCY1, ADCYAP1R1 | ADCY8 11/4885ADCY1 2/4885POLB 4587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.