Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 3/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.36 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.36 |
| ▸ | BAZ2B | Q9UIF8 | 3/20 | 0.35 |
| ▸ | BAZ2A | Q9UIF9 | 3/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20674161 | 0.80 | MAP2K3 (0.46) | ALDH1A1KDM4EL3MBTL1MEN1MAPT | |
| SCHEMBL20674150 | 0.80 | BAZ2B (0.46) | ALDH1A1KDM4EL3MBTL1MEN1MAPT | |
| SCHEMBL20674510 | 0.76 | CNR2 (0.44) | ALDH1A1KDM4EKMT2ACNR2GAA | |
| SCHEMBL20674628 | 0.74 | MAP2K3 (0.40) | ALDH1A1KDM4EL3MBTL1MEN1MAPT | |
| SCHEMBL20674156 | 0.73 | HIF1A (0.43) | ALDH1A1KDM4EL3MBTL1MEN1MAPT | |
| SCHEMBL20674504 | 0.68 | PTPN1 (0.56) | ALDH1A1KDM4EL3MBTL1MEN1MAPT | |
| SCHEMBL20674505 | 0.68 | ALDH1A1 (0.56) | ALDH1A1KDM4EL3MBTL1MEN1MAPT | |
| SCHEMBL20673874 | 0.68 | USP7 (0.53) | ALDH1A1KDM4EL3MBTL1MEN1MAPT | |
| SCHEMBL20673884 | 0.65 | USP7 (0.48) | ALDH1A1KDM4EMEN1MAPTKMT2A | |
| SCHEMBL20674500 | 0.65 | KDM4E (0.43) | ALDH1A1KDM4EL3MBTL1MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10435388-B2 | Selective inhibitors of clinically important mutants of the EGFR tyrosine kinase | CS PHARMATECH LIMITED (KY) | 2019-10-08 | — | — | US | disclosed |
| US-20190023689-A1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | HIGH GREAT INVESTMENT LIMITED (HK) | 2019-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10435388-B2 | Selective inhibitors of clinically important mutants of the EGFR tyrosine kinase | EGFR, ERBB3, ERBB2 | ALDH1A1 3193/4885KDM4E 1867/4885L3MBTL1 324/4885 |
| US-20190023689-A1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | EGFR, ERBB3, ERBB2 | ALDH1A1 3193/4885KDM4E 1867/4885L3MBTL1 324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.