Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.41 |
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | HNF4A | P41235 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1524220 | 0.83 | BACE1 (0.56) | BACE1HDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL19664921 | 0.79 | BACE1 (0.41) | BACE1HDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL10338501 | 0.75 | BACE1 (0.52) | BACE1HDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL1697209 | 0.74 | BACE1 (0.62) | BACE1HDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL15509349 | 0.73 | MAPK1 (0.52) | BACE1HDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL4647831 | 0.72 | HDAC4 (0.54) | BACE1HDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL29001722 | 0.71 | PDE4B (0.58) | BACE1HDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL1754108 | 0.71 | PDE4B (0.52) | BACE1HDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL49916 | 0.71 | BACE1 (0.58) | BACE1HDAC4HDAC2HDAC8HDAC6 | |
| Phosphoric Acid SCHEMBL10438539 | 0.70 | PDE4B (0.54) | BACE1HDAC4HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148831-B2 | Latent catalyst for epoxy resin, epoxy resin composition, and semiconductor device | SUMITOMO BAKELITE COMPANY, LTD. (JP) | 2012-04-03 | — | — | US | disclosed |