Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 18/20 | 1.00 |
| ▸ | CDK6 | Q00534 | 10/20 | 1.00 |
| ▸ | CDK2 | P24941 | 6/20 | 0.72 |
| ▸ | CDK1 | P06493 | 2/20 | 0.72 |
| ▸ | CCND1 | P24385 | 5/20 | 0.59 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.59 |
| ▸ | CCND3 | P30281 | 2/20 | 0.59 |
| ▸ | GAK | O14976 | 1/20 | 0.59 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.59 |
| ▸ | FECH | P22830 | 1/20 | 0.59 |
| ▸ | CDK9 | P50750 | 1/20 | 0.59 |
| ▸ | CDK16 | Q00536 | 1/20 | 0.59 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.59 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.59 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.59 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.59 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.59 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.59 |
| ▸ | CCND2 | P30279 | 1/20 | 0.57 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL20676973 | 0.99 | CDK4 (0.98) | CDK4CDK6CDK2CDK1CCND1 | |
| SCHEMBL20677024 | 0.88 | CDK4 (1.00) | CDK4CDK6CDK2CCND1CCNA2 | |
| Hydrochloric Acid SCHEMBL20677045 | 0.87 | CDK4 (0.98) | CDK4CDK6CDK2CCND1CCNA2 | |
| SCHEMBL29507546 | 0.85 | CDK4 (0.73) | CDK4CDK6CDK2CDK1CCND1 | |
| SCHEMBL303942 | 0.84 | CDK1 (0.82) | CDK4CDK6CDK2CDK1CCND1 | |
| SCHEMBL30176495 | 0.84 | CDK1 (0.82) | CDK4CDK6CDK2CDK1CCND1 | |
| SCHEMBL303554 | 0.84 | CDK2 (1.00) | CDK4CDK6CDK2CDK1CCND1 | |
| SCHEMBL29507585 | 0.84 | CDK2 (1.00) | CDK4CDK6CDK2CDK1CCND1 | |
| Dimethylamine SCHEMBL28726043 | 0.83 | CDK4 (0.71) | CDK4CDK6CDK2CDK1CCND1 | |
| SCHEMBL20683903 | 0.83 | CDK2 (0.72) | CDK4CDK6CDK2CDK1CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108884101-B | Substituted pyrrolopyrimidine CDK inhibitors, pharmaceutical compositions containing the same and their use | 正大天晴药业集团股份有限公司 | 2020-07-24 | — | — | CN | disclosed |
| US-10570141-B2 | Substituted pyrrolopyrimidine CDK inhibitor, pharmaceutical composition containing same and use thereof | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2020-02-25 | — | — | US | disclosed |
| US-10570141-B2 | Substituted pyrrolopyrimidine CDK inhibitor, pharmaceutical composition containing same and use thereof | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2020-02-25 | — | — | US | disclosed |
| US-20190300533-A1 | SUBSTITUTED PYRROLOPYRIMIDINE CDK INHIBITOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME AND USE THEREOF | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2019-10-03 | — | — | US | disclosed |
| US-20190300533-A1 | SUBSTITUTED PYRROLOPYRIMIDINE CDK INHIBITOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME AND USE THEREOF | CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) | 2019-10-03 | — | — | US | disclosed |
| EP-3434676-A1 | SUBSTITUTED PYRROLOPYRIMIDINE CDK INHIBITOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME AND USE THEREOF | Chai Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2019-01-30 | — | — | EP | disclosed |
| EP-3434676-A1 | SUBSTITUTED PYRROLOPYRIMIDINE CDK INHIBITOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME AND USE THEREOF | Chai Tai Tianqing Pharmaceutical Group Co., Ltd. (CN) | 2019-01-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10570141-B2 | Substituted pyrrolopyrimidine CDK inhibitor, pharmaceutical composition containing same and use thereof | CDK6, CDK9, CDK3 | CDK4 5/4885CDK6 1/4885CDK2 13/4885 |
| US-20190300533-A1 | SUBSTITUTED PYRROLOPYRIMIDINE CDK INHIBITOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME AND USE THEREOF | CDK6, CDK9, CDK3 | CDK4 5/4885CDK6 1/4885CDK2 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.