Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 7/20 | 0.46 |
| ▸ | MGLL | Q99685 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | FAAH | O00519 | 3/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28630111 | 0.93 | SMN1; SMN2 (0.51) | HTTSMN1; SMN2HPGDPTGS1PTGS2 | |
| SCHEMBL31694371 | 0.89 | HTT (0.48) | HTTSMN1; SMN2HPGDPTGS1PTGS2 | |
| SCHEMBL22910736 | 0.89 | PTGS1 (0.49) | HTTSMN1; SMN2HPGDPTGS1PTGS2 | |
| SCHEMBL17841853 | 0.88 | HTT (0.49) | HTTSMN1; SMN2HPGDPTGS1PTGS2 | |
| SCHEMBL16107013 | 0.88 | SMN1; SMN2 (0.49) | HTTSMN1; SMN2HPGDPTGS1PTGS2 | |
| SCHEMBL17841851 | 0.88 | HTT (0.49) | HTTSMN1; SMN2HPGDPTGS1PTGS2 | |
| SCHEMBL24686272 | 0.86 | HPGD (0.63) | HTTSMN1; SMN2HPGDPTGS1PTGS2 | |
| SCHEMBL24687409 | 0.86 | HPGD (0.63) | HTTSMN1; SMN2HPGDPTGS1PTGS2 | |
| SCHEMBL24686939 | 0.86 | HPGD (0.63) | HTTSMN1; SMN2HPGDPTGS1PTGS2 | |
| SCHEMBL24686941 | 0.86 | HPGD (0.63) | HTTSMN1; SMN2HPGDPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3432934-A1 | PRODRUGS OF CYTOTOXIC ACTIVE AGENTS HAVING ENZYMATICALLY CLEAVABLE GROUPS | Bayer Pharma Aktiengesellschaft (DE) | 2019-01-30 | — | — | EP | disclosed |