E626

E626

SCHEMBL20677331

Nc1nc2c(ncn2[C@@H]2O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]1.Nc1nc2c(ncn2[C@@H]2O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)[nH]1

nearest known ligand 0.83

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NT5E P21589 1/20 0.83
IMPDH2 P12268 7/20 0.76
IMPDH1 P20839 2/20 0.76
TGM2 P21980 1/20 0.76
TAS1R3 Q7RTX0 2/20 0.73
TAS1R1 Q7RTX1 2/20 0.73
KRAS P01116 6/20 0.69
CA5A P35218 1/20 0.68
HINT1 P49773 1/20 0.68
FUT5 Q11128 1/20 0.68
DNPH1 O43598 1/20 0.66
PRKAB2 O43741 1/20 0.66
TRPM2 O94759 1/20 0.66
LDHA P00338 1/20 0.66
ADRB2 P07550 1/20 0.66
FBP1 P09467 1/20 0.66
SRC P12931 1/20 0.66
ADORA1 P30542 1/20 0.66
P2RY2 P41231 1/20 0.66
P2RY1 P47900 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
E626 SCHEMBL5854 1.00 NT5E (0.83) NT5EIMPDH2IMPDH1TGM2TAS1R3
E626 SCHEMBL18785103 1.00 NT5E (0.83) NT5EIMPDH2IMPDH1TGM2TAS1R3
E626 SCHEMBL20276926 1.00 NT5E (0.83) NT5EIMPDH2IMPDH1TGM2TAS1R3
E626 SCHEMBL18759049 1.00 NT5E (0.83) NT5EIMPDH2IMPDH1TGM2TAS1R3
E626 SCHEMBL9980018 1.00 NT5E (0.83) NT5EIMPDH2IMPDH1TGM2TAS1R3
E626 SCHEMBL18763818 1.00 NT5E (0.83) NT5EIMPDH2IMPDH1TGM2TAS1R3
E626 SCHEMBL13497991 1.00 NT5E (0.83) NT5EIMPDH2IMPDH1TGM2TAS1R3
E626 SCHEMBL21163348 1.00 NT5E (0.83) NT5EIMPDH2IMPDH1TGM2TAS1R3
E626 SCHEMBL21803790 1.00 NT5E (0.83) NT5EIMPDH2IMPDH1TGM2TAS1R3
E626 SCHEMBL20277596 1.00 NT5E (0.83) NT5EIMPDH2IMPDH1TGM2TAS1R3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117235625-A Drilling process drill string vibration identification method based on multi-scale time convolution network 中国地质大学(武汉) 2023-12-15 CN claimed
CN-109113386-A GMP sterile purification workshop 天津市爱德恒业科技发展有限公司 2019-01-01 CN claimed
CN-106822008-A A kind of vitamin D dissolution formulation and preparation method thereof 江苏艾兰得营养品有限公司 2017-06-13 CN claimed
CN-103019121-B Computer-based intelligent control method for food safety and quality PSYCHOREALITY SOOCHOW IND DESIGN STUDIO 2015-01-07 CN claimed
CN-103019121-A Computer-based intelligent control method for food safety and quality PSYCHOREALITY SOOCHOW IND DESIGN STUDIO 2013-04-03 CN claimed
US-20240100136-A1 CHIMERIC ADAPTOR PROTEINS AND METHODS OF REGULATING GENE EXPRESSION FUNDAÇÃO D. ANNA DE SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD FOUNDATION (PT) 2024-03-28 US disclosed
CN-117235625-A Drilling process drill string vibration identification method based on multi-scale time convolution network 中国地质大学(武汉) 2023-12-15 CN disclosed
EP-4114955-A1 CHIMERIC ADAPTOR PROTEINS AND METHODS OF REGULATING GENE EXPRESSION Refuge Biotechnologies, Inc. (US) 2023-01-11 EP disclosed
WO-2021178667-A1 CHIMERIC ADAPTOR PROTEINS AND METHODS OF REGULATING GENE EXPRESSION REFUGE BIOTECHNOLOGIES, INC. (US) 2021-09-10 WO disclosed
EP-3433148-A1 METHOD FOR CONTROLLING AN ELECTRIC ASSISTANCE TORQUE Renault S.A.S. (FR) 2019-01-30 EP disclosed
CN-108896520-A The ratio fluorescent method of principle is inhibited to detect As (V) based on activity of acid phosphatase 南昌大学 2018-11-27 CN disclosed
CN-207103392-U A kind of tablet press machine air-out apparatus for reducing space-pollution 河南省奥林特药业有限公司 2018-03-16 CN disclosed
CN-203571968-U Air conditioner purifying system FUJIAN NANSHAOLIN PHARMACEUTICAL CO LTD 2014-04-30 CN disclosed
CN-103019121-A Computer-based intelligent control method for food safety and quality PSYCHOREALITY SOOCHOW IND DESIGN STUDIO 2013-04-03 CN disclosed
CN-202037811-U Valve pin type injection mold KUNMING NANJIANG PHARMACEUTICAL CO LTD 2011-11-16 CN disclosed
CN-101137743-B Escherichia strain capable of converting xmp to gmp and maintaining the inactivated state of gene(s) associated with gmp degradation and methods of using the same CJ CHEI I JEDANG CORP 2010-12-08 CN disclosed
CN-101137743-A Escherichia strain capable of converting xmp to gmp and maintaining the inactivated state of gene(s) associated with gmp degradation and methods of using the same CJ CORP (KR) 2008-03-05 CN disclosed
CN-1640416-A Black-bone-chicken liquor for tonifying blood SHENGWUGU SCIENCE TECHNOLOGY I (CN) 2005-07-20 CN disclosed
CN-1640325-A Hesheng black-bone chichen and liquid SHENGWUGU SCIENCE TECHNOLOGY I (CN) 2005-07-20 CN disclosed
CN-2704799-Y Extract vacuum driers SHEN SHANMING (CN) 2005-06-15 CN disclosed