Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 3/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1468200 | 0.90 | HDAC3 (0.51) | HDAC3HDAC1HDAC6KDM4ELMNA | |
| SCHEMBL21812621 | 0.86 | HDAC3 (0.55) | HDAC3HDAC1HDAC6KDM4ELMNA | |
| SCHEMBL1852466 | 0.85 | HDAC3 (0.52) | HDAC3HDAC1HDAC6KDM4ELMNA | |
| SCHEMBL17295921 | 0.85 | HDAC3 (0.52) | HDAC3HDAC1HDAC6KDM4ELMNA | |
| SCHEMBL19370070 | 0.85 | HDAC3 (0.52) | HDAC3HDAC1HDAC6KDM4ELMNA | |
| SCHEMBL2173142 | 0.84 | HDAC3 (0.51) | HDAC3HDAC1HDAC6KDM4ELMNA | |
| SCHEMBL21916541 | 0.83 | HDAC3 (0.50) | HDAC3HDAC1HDAC6KDM4ELMNA | |
| SCHEMBL7145374 | 0.81 | ABCB1 (0.54) | HDAC3HDAC1HDAC6CYP1A2POLB | |
| SCHEMBL16020352 | 0.80 | HDAC3 (0.48) | HDAC3HDAC1HDAC6KDM4ELMNA | |
| SCHEMBL215719 | 0.80 | HDAC3 (0.51) | HDAC3HDAC1HDAC6KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190031650-A1 | DNA ALKYLATION AND CROSS-LINKING AGENTS AS COMPOUNDS AND PAYLOADS FOR TARGETED THERAPIES | UNIV YALE (US) | 2019-01-31 | — | — | US | disclosed |
| US-20190031650-A1 | DNA ALKYLATION AND CROSS-LINKING AGENTS AS COMPOUNDS AND PAYLOADS FOR TARGETED THERAPIES | UNIV YALE (US) | 2019-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190031650-A1 | DNA ALKYLATION AND CROSS-LINKING AGENTS AS COMPOUNDS AND PAYLOADS FOR TARGETED THERAPIES | PCNA, TOP2B, DCLRE1A | HDAC3 817/4885HDAC1 655/4885HDAC6 890/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.