Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cytisinicline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 known ✓ | P17787 | 10/20 | 0.82 |
| ▸ | CHRNA4 known ✓ | P43681 | 10/20 | 0.82 |
| ▸ | CHRNB4 | P30926 | 8/20 | 0.82 |
| ▸ | CHRNA3 | P32297 | 8/20 | 0.82 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.82 |
| ▸ | MEN1 | O00255 | 2/20 | 0.82 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.82 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.82 |
| ▸ | CHRNG | P07510 | 2/20 | 0.82 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.82 |
| ▸ | CHRND | Q07001 | 2/20 | 0.82 |
| ▸ | LMNA | P02545 | 1/20 | 0.82 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.82 |
| ▸ | MAPT | P10636 | 1/20 | 0.82 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cytisinicline SCHEMBL1500403 | 0.95 | CHRNB2 (0.86) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| Cytisinicline SCHEMBL161398 | 0.91 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| Cytisinicline SCHEMBL14870500 | 0.91 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| Cytisinicline SCHEMBL8309064 | 0.91 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| Cytisinicline SCHEMBL1500421 | 0.91 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| Cytisinicline SCHEMBL13595657 | 0.91 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| Cytisinicline SCHEMBL472026 | 0.91 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| Cytisinicline SCHEMBL19877933 | 0.89 | CHRNB2 (0.97) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| Cytisinicline SCHEMBL29903945 | 0.89 | CHRNB2 (0.97) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 | |
| Cytisinicline SCHEMBL20680750 | 0.84 | CHRNB2 (0.80) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220380369-A1 | CYTISINE SALTS | ACHIEVE LIFE SCIENCES, INC. | 2022-12-01 | — | — | US | disclosed |
| US-11459328-B2 | Cytisine salts | ACHIEVE PHARMA UK LIMITED | 2022-10-04 | — | — | US | disclosed |
| US-20200190085-A1 | CYTISINE SALTS | ACHIEVE PHARMA UK LIMITED (GB) | 2020-06-18 | — | — | US | disclosed |
| CN-111278826-A | Wild indigo base salt | 英国雅琪制药有限公司 | 2020-06-12 | — | — | CN | disclosed |
| EP-3658561-A1 | CYTISINE SALTS | Achieve Pharma UK Limited (GB) | 2020-06-03 | — | — | EP | disclosed |
| WO-2019020993-A1 | CYTISINE SALTS | ACHIEVE PHARMA UK LIMITED (GB) | 2019-01-31 | — | — | WO | disclosed |