Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 9/20 | 0.61 |
| ▸ | ARG2 | P78540 | 9/20 | 0.61 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.49 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10265453 | 0.94 | ARG1 (0.63) | ARG1ARG2GRM2GRM3SIGMAR1 | |
| SCHEMBL19055967 | 0.88 | ARG1 (0.77) | ARG1ARG2GRM2GRM3SIGMAR1 | |
| SCHEMBL16309661 | 0.88 | ARG1 (0.77) | ARG1ARG2GRM2GRM3SIGMAR1 | |
| SCHEMBL10265155 | 0.88 | ARG1 (0.77) | ARG1ARG2GRM2GRM3SIGMAR1 | |
| SCHEMBL894867 | 0.88 | ARG1 (0.80) | ARG1ARG2 | |
| SCHEMBL27903250 | 0.88 | ARG1 (0.80) | ARG1ARG2 | |
| Hydrochloric Acid SCHEMBL27921005 | 0.87 | ARG1 (0.78) | ARG1ARG2 | |
| SCHEMBL20683512 | 0.85 | ARG1 (0.53) | ARG1ARG2HTR2ASIGMAR1 | |
| SCHEMBL20683471 | 0.84 | ARG1 (0.67) | ARG1ARG2GRM2GRM3 | |
| SCHEMBL894654 | 0.82 | ARG1 (0.80) | ARG1ARG2GRM2GRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560978-B1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | MARS INC (US) | 2019-01-30 | — | — | EP | disclosed |