Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 6/20 | 0.56 |
| ▸ | ARG2 | P78540 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | ATM | Q13315 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | SCD | O00767 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL895081 | 0.89 | ARG1 (0.73) | ARG1ARG2KDM4EALDH1A1ATM | |
| SCHEMBL30169886 | 0.89 | ARG1 (0.73) | ARG1ARG2KDM4EALDH1A1ATM | |
| Hydrochloric Acid SCHEMBL895977 | 0.88 | ARG1 (0.71) | ARG1ARG2KDM4EALDH1A1ATM | |
| SCHEMBL20683511 | 0.84 | ARG1 (0.57) | ARG1ARG2KDM4EALDH1A1 | |
| SCHEMBL10265155 | 0.83 | ARG1 (0.77) | ARG1ARG2KMT2AMEN1SIGMAR1 | |
| SCHEMBL19055967 | 0.83 | ARG1 (0.77) | ARG1ARG2KMT2AMEN1SIGMAR1 | |
| SCHEMBL16309661 | 0.83 | ARG1 (0.77) | ARG1ARG2KMT2AMEN1SIGMAR1 | |
| SCHEMBL20683410 | 0.82 | ARG1 (0.54) | ARG1ARG2KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL20683466 | 0.80 | ARG1 (0.52) | ARG1ARG2KDM4EALDH1A1TDP1 | |
| SCHEMBL20683430 | 0.79 | ARG1 (0.51) | ARG1ARG2KDM4EALDH1A1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2560978-B1 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS | MARS INC (US) | 2019-01-30 | — | — | EP | disclosed |