SCHEMBL20684195

SCHEMBL20684195

CCc1ccc(N(CC(C)C)S(=O)(=O)c2ccc(Br)c([SiH2]C)c2)cc1

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RORC P51449 20/20 0.48
IL17A Q16552 5/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17843338 0.83 RORC (0.62) RORCIL17A
SCHEMBL17843388 0.82 MCL1 (0.52) RORCIL17A
SCHEMBL17843299 0.82 RORC (0.63) RORCIL17A
SCHEMBL15981011 0.82 RORC (0.53) RORC
SCHEMBL14831323 0.82 MCL1 (0.57) RORC
SCHEMBL28503119 0.81 RORC (0.52) RORCIL17A
SCHEMBL17843349 0.81 RORC (0.55) RORCIL17A
SCHEMBL14831320 0.80 RORC (0.56) RORCIL17A
SCHEMBL17858289 0.78 RORC (0.52) RORCIL17A
SCHEMBL17843295 0.76 MCL1 (0.58) RORCIL17A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3233848-B1 BENZENESULFONAMIDE DERIVATIVES AS INVERSE AGONISTS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR GAMMA (T)) GALDERMA RES & DEV (FR) 2019-01-30 EP disclosed