Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 4/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 4/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.37 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | IDH2 | P48735 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20688036 | 0.92 | TYK2 (0.56) | TYK2HRH4EPHX2IKBKBIDH2 | |
| SCHEMBL20697158 | 0.85 | TYK2 (0.47) | TYK2HRH4PRKDCIKBKBKDM4E | |
| SCHEMBL21227305 | 0.85 | TYK2 (0.47) | TYK2HRH4EPHX2PRKDCIKBKB | |
| SCHEMBL22272972 | 0.81 | TYK2 (0.55) | TYK2HRH4EPHX2HRH3 | |
| SCHEMBL20697275 | 0.79 | HRH4 (0.48) | TYK2HRH4PRKDCIKBKBGRIN2D | |
| SCHEMBL22873765 | 0.79 | HRH4 (0.47) | TYK2HRH4PRKDCIKBKBHRH3 | |
| SCHEMBL22873583 | 0.79 | HRH4 (0.47) | TYK2HRH4PRKDCIKBKBHRH3 | |
| SCHEMBL20697163 | 0.79 | TYK2 (0.49) | TYK2HRH4IKBKBIDH2KDM4E | |
| SCHEMBL22272970 | 0.77 | CRHBP (0.53) | TYK2HRH4EPHX2KDM4EUSP2 | |
| SCHEMBL5789047 | 0.77 | HRH4 (0.66) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019023468-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2019-01-31 | — | — | WO | disclosed |