Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 4/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20678811 | 0.89 | KDM4E (0.41) | HPGDALDH1A1MAPTKDM4EUSP2 | |
| SCHEMBL20688967 | 0.88 | KDM4E (0.41) | HPGDALDH1A1MAPTKDM4EUSP2 | |
| SCHEMBL20689148 | 0.87 | CSNK1D (0.34) | HPGDCYP1A1ALDH1A1MAPTKDM4E | |
| SCHEMBL20688901 | 0.87 | ALDH1A1 (0.45) | HPGDALDH1A1KDM4EPOLBHSD17B10 | |
| SCHEMBL20687904 | 0.87 | TYK2 (0.37) | HPGDALDH1A1KDM4EHSD17B10L3MBTL1 | |
| SCHEMBL21246014 | 0.86 | TP53 (0.46) | HPGDCYP1A1ALDH1A1MAPTKDM4E | |
| SCHEMBL20689423 | 0.85 | ALDH1A1 (0.48) | HPGDALDH1A1MAPTKDM4EUSP2 | |
| SCHEMBL20689010 | 0.85 | TYK2 (0.44) | HPGDCYP1A1LMNACSNK1DTYK2 | |
| SCHEMBL20687901 | 0.85 | TYK2 (0.44) | TYK2 | |
| SCHEMBL21948221 | 0.83 | IRAK4 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019023468-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2019-01-31 | — | — | WO | disclosed |