Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | STK17B | O94768 | 1/20 | 0.30 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.30 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.30 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21258474 | 0.87 | — | — | |
| SCHEMBL21948221 | 0.85 | IRAK4 (0.33) | HSP90AA1HSP90AB1 | |
| SCHEMBL20687904 | 0.84 | TYK2 (0.37) | — | |
| SCHEMBL20627800 | 0.84 | GSK3B (0.32) | HSP90AA1HSP90AB1CDK2 | |
| SCHEMBL20689134 | 0.84 | PAX8 (0.31) | HSP90AA1HSP90AB1 | |
| SCHEMBL20678811 | 0.84 | KDM4E (0.41) | — | |
| SCHEMBL25069828 | 0.84 | SUV39H2 (0.34) | — | |
| SCHEMBL21948869 | 0.83 | MALT1 (0.32) | HSP90AA1HSP90AB1 | |
| SCHEMBL20689057 | 0.82 | MALT1 (0.31) | — | |
| SCHEMBL17032221 | 0.82 | MALT1 (0.33) | CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019023468-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2019-01-31 | — | — | WO | disclosed |