Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | MGAM | O43451 | 1/20 | 0.48 |
| ▸ | SI | P14410 | 1/20 | 0.48 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.34 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2069035 | 1.00 | GAA (0.48) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL24999670 | 0.87 | GAA (0.44) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL28653935 | 0.87 | GAA (0.44) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL21342973 | 0.87 | GAA (0.44) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL15496396 | 0.84 | GAA (0.50) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL29210122 | 0.82 | ALDH1A1 (0.44) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL29210123 | 0.82 | ALDH1A1 (0.44) | GAAMGAMSIMGAM2ALDH1A1 | |
| Potassium Ion SCHEMBL11280017 | 0.78 | ALDH1A1 (0.41) | GAAMGAMSIMGAM2ALDH1A1 | |
| Potassium Ion SCHEMBL11280014 | 0.78 | ALDH1A1 (0.41) | GAAMGAMSIMGAM2ALDH1A1 | |
| SCHEMBL9714131 | 0.77 | GAA (0.48) | GAAMGAMSIMGAM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0132375-A2 | Dihydropyridine anti-ischaemic and antihypertensive agents | Pfizer Limited (GB) | 1985-01-30 | — | — | EP | claimed |
| US-7906546-B2 | Tetrahydrocarbazoles and derivatives | HOFFMANN-LA ROCHE INC. (US) | 2011-03-15 | — | — | US | disclosed |
| US-20100216833-A1 | TETRAHYDROCARBAZOLES AND DERIVATIVES | DEHMLOW HENRIETTA | 2010-08-26 | — | — | US | disclosed |
| EP-1732892-B1 | TETRAHYDROCARBAZOLES AND DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2008-09-17 | — | — | EP | disclosed |
| EP-1732892-A1 | TETRAHYDROCARBAZOLES AND DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092856-A1 | TETRAHYDROCARBAZOLES AND DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-10-06 | — | — | WO | disclosed |
| US-20050215577-A1 | Tetrahydrocarbazoles and derivatives | HOFFMANN-LA ROCHE INC. | 2005-09-29 | — | — | US | disclosed |
| US-4568677-A | CONTROLLED COOLING | PFIZER INC. (US) | 1986-02-04 | — | — | US | disclosed |
| EP-0132375-A2 | Dihydropyridine anti-ischaemic and antihypertensive agents | Pfizer Limited (GB) | 1985-01-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216833-A1 | TETRAHYDROCARBAZOLES AND DERIVATIVES | NR1H3, NR1H2, NR1H4 | GAA 3456/4885MGAM 4121/4885SI 297/4885 |
| US-20050215577-A1 | Tetrahydrocarbazoles and derivatives | NR1H3, NR1H2, NR1H4 | GAA 3456/4885MGAM 4121/4885SI 297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.