SCHEMBL2069083

SCHEMBL2069083

COC(c1sc(-c2ccc(Cl)cc2)nc1C)C1CN(C(=O)OC(C)(C)C)CCO1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1D1 P20393 2/20 0.37
KCNK3 O14649 1/20 0.37
KCNK9 Q9NPC2 1/20 0.37
FAAH O00519 2/20 0.37
RAB9A P51151 2/20 0.36
KDM4E B2RXH2 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
NPC1 O15118 1/20 0.36
POLB P06746 1/20 0.36
PPARA Q07869 1/20 0.36
HRH3 Q9Y5N1 1/20 0.36
MEN1 O00255 3/20 0.36
KMT2A Q03164 3/20 0.36
ALDH1A1 P00352 1/20 0.36
MAPT P10636 1/20 0.36
CNR1 P21554 1/20 0.35
CNR2 P34972 1/20 0.35
USP2 O75604 1/20 0.35
HPGD P15428 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2069078 0.84 CNR1 (0.43) KCNK3KCNK9PPARAHRH3MEN1
SCHEMBL2069085 0.76 PPARA (0.42) NR1D1RAB9APPARAMEN1KMT2A
SCHEMBL2072130 0.75 PPARA (0.42) NR1D1SMN1; SMN2PPARAMAPTNPSR1
SCHEMBL2069412 0.75 PPARA (0.61) RAB9AKDM4ESMN1; SMN2NPC1POLB
SCHEMBL2070132 0.73 SLC6A4 (0.44) RAB9AKDM4ESMN1; SMN2NPC1POLB
SCHEMBL2069079 0.69 PPARA (0.48) NR1D1PPARAHRH3MEN1KMT2A
SCHEMBL2069575 0.69 MEN1 (0.48) RAB9AKDM4ESMN1; SMN2NPC1POLB
SCHEMBL2069948 0.69 PPARA (0.61) NR1D1RAB9APPARAHRH3MEN1
SCHEMBL2069528 0.69 PPARA (0.63) SMN1; SMN2PPARACNR1CNR2
SCHEMBL2069365 0.69 PPARA (0.63) SMN1; SMN2PPARACNR1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7902367-B2 Cyclic amino benzoic acid derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2011-03-08 US disclosed
US-20070249580-A1 Novel Cyclic Amino Benzoic Acid Derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2007-10-25 US disclosed
CN-101014595-A Novel cyclic aminobenzoic acid derivative KYORIN SEIYAKU KK (JP) 2007-08-08 CN disclosed
EP-1780210-A1 NOVEL CYCLIC AMINOBENZOIC ACID DERIVATIVE Kyorin Pharmaceutical Co., Ltd. (JP) 2007-05-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070249580-A1 Novel Cyclic Amino Benzoic Acid Derivative PPARA, PPARG, PPARD NR1D1 136/4885KCNK3 3783/4885KCNK9 4109/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.