SCHEMBL2070132

SCHEMBL2070132

COC(c1sc(-c2ccc(Cl)cc2)nc1C)C1CNCCO1

nearest known ligand 0.44

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 15/20 0.44
SLC6A2 P23975 14/20 0.44
SLC6A3 Q01959 10/20 0.44
KCNH2 Q12809 1/20 0.42
HRH1 P35367 1/20 0.42
RAB9A P51151 2/20 0.36
KDM4E B2RXH2 1/20 0.36
NPC1 O15118 1/20 0.36
POLB P06746 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
CASP3 P42574 1/20 0.36
SENP8 Q96LD8 1/20 0.36
SENP7 Q9BQF6 1/20 0.36
SENP6 Q9GZR1 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2070575 0.80 SLC6A4 (0.41) SLC6A4SLC6A2SLC6A3KCNH2RAB9A
SCHEMBL2069083 0.73 NR1D1 (0.37) RAB9AKDM4ENPC1POLBSMN1; SMN2
SCHEMBL2071322 0.71 PPARA (0.41) SLC6A4SLC6A3RAB9AKDM4ENPC1
SCHEMBL2070135 0.70 FFAR1 (0.41) SLC6A4SLC6A2SLC6A3RAB9AKDM4E
SCHEMBL2069754 0.70 PPARA (0.55) KDM4E
SCHEMBL84927 0.67 RAB9A (0.54) RAB9AKDM4ENPC1POLBSMN1; SMN2
SCHEMBL25883422 0.67 SLC6A2 (0.45) SLC6A4SLC6A2SLC6A3KCNH2HRH1
SCHEMBL2068822 0.66 PPARA (0.58) RAB9AKDM4ENPC1POLBSMN1; SMN2
SCHEMBL2069690 0.66 MAPT (0.46) RAB9AKDM4ENPC1POLBSMN1; SMN2
SCHEMBL11436272 0.65 SLC6A2 (0.63) SLC6A4SLC6A2SLC6A3KCNH2HRH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7902367-B2 Cyclic amino benzoic acid derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2011-03-08 US disclosed
US-20070249580-A1 Novel Cyclic Amino Benzoic Acid Derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2007-10-25 US disclosed
CN-101014595-A Novel cyclic aminobenzoic acid derivative KYORIN SEIYAKU KK (JP) 2007-08-08 CN disclosed
EP-1780210-A1 NOVEL CYCLIC AMINOBENZOIC ACID DERIVATIVE Kyorin Pharmaceutical Co., Ltd. (JP) 2007-05-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070249580-A1 Novel Cyclic Amino Benzoic Acid Derivative PPARA, PPARG, PPARD SLC6A4 1813/4885SLC6A2 2893/4885SLC6A3 2049/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.