Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 20/20 | 1.00 |
| ▸ | CDK7 | P50613 | 8/20 | 1.00 |
| ▸ | CDK2 | P24941 | 6/20 | 1.00 |
| ▸ | CDK13 | Q14004 | 2/20 | 1.00 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 1.00 |
| ▸ | CCNT1 | O60563 | 19/20 | 0.88 |
| ▸ | CCNH | P51946 | 7/20 | 0.88 |
| ▸ | CDK4 | P11802 | 8/20 | 0.75 |
| ▸ | CCND1 | P24385 | 8/20 | 0.75 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.75 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.75 |
| ▸ | CDK3 | Q00526 | 5/20 | 0.75 |
| ▸ | CDK1 | P06493 | 4/20 | 0.69 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.69 |
| ▸ | CDK6 | Q00534 | 3/20 | 0.69 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.69 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.69 |
| ▸ | CCNK | O75909 | 1/20 | 0.69 |
| ▸ | CDK14 | O94921 | 1/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21877791 | 1.00 | CDK9 (1.00) | CDK9CDK7CDK2CDK13CDK12 | |
| SCHEMBL21946118 | 0.94 | CDK9 (1.00) | CDK9CDK7CDK2CDK13CDK12 | |
| SCHEMBL21877636 | 0.91 | CDK9 (0.83) | CDK9CDK7CDK2CDK13CDK12 | |
| SCHEMBL21877710 | 0.91 | CDK9 (0.83) | CDK9CDK7CDK2CDK13CDK12 | |
| SCHEMBL21946120 | 0.86 | CDK9 (1.00) | CDK9CDK7CDK2CDK13CDK12 | |
| SCHEMBL26871376 | 0.85 | CDK9 (0.74) | CDK9CDK7CDK2CDK13CDK12 | |
| SCHEMBL23959016 | 0.85 | CDK9 (0.73) | CDK9CDK7CDK2CDK13CDK12 | |
| SCHEMBL25477504 | 0.85 | CDK9 (0.74) | CDK9CDK7CDK2CDK13CDK12 | |
| SCHEMBL24174222 | 0.84 | CDK9 (0.73) | CDK9CDK7CDK2CDK13CDK12 | |
| SCHEMBL21946121 | 0.84 | CDK9 (0.73) | CDK9CDK7CDK2CDK13CDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024178067-A9 | CHIMERIC DEGRADERS OF CYCLIN-DEPENDENT KINASE 9 AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2025-02-06 | — | — | WO | disclosed |
| WO-2024178067-A1 | CHIMERIC DEGRADERS OF CYCLIN-DEPENDENT KINASE 9 AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2024-08-29 | — | — | WO | disclosed |
| US-20240132506-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CDK9 ACTIVITY | Kronos Bio, Inc. (US) | 2024-04-25 | — | — | US | disclosed |
| US-11845754-B2 | Substituted pyrazolo[1,5-a]pyrimidines for modulating CDK9 activity | Kronos Bio, Inc. (US) | 2023-12-19 | — | — | US | disclosed |
| CN-112996790-B | Compounds, compositions and methods for modulating CDK9 activity | 克洛诺斯生物公司 | 2023-11-03 | — | — | CN | disclosed |
| US-20230158159-A1 | CHIMERIC DEGRADERS OF CYCLIN-DEPENDENT KINASE 9 AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2023-05-25 | — | — | US | disclosed |
| US-20230158159-A1 | CHIMERIC DEGRADERS OF CYCLIN-DEPENDENT KINASE 9 AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2023-05-25 | — | — | US | disclosed |
| US-20230158159-A1 | CHIMERIC DEGRADERS OF CYCLIN-DEPENDENT KINASE 9 AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2023-05-25 | — | — | US | disclosed |
| US-20220002305-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CDK9 ACTIVITY | Kronos Bio, Inc. (US) | 2022-01-06 | — | — | US | disclosed |
| US-20220002305-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CDK9 ACTIVITY | Kronos Bio, Inc. (US) | 2022-01-06 | — | — | US | disclosed |
| WO-2021216828-A1 | CHIMERIC DEGRADERS OF CYCLIN-DEPENDENT KINASE 9 AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2021-10-28 | — | — | WO | disclosed |
| US-11155560-B2 | Substituted pyrazolo[1,5-a]pyrimidines for modulating CDK9 activity | Kronos Bio, Inc. (US) | 2021-10-26 | — | — | US | disclosed |
| US-11155560-B2 | Substituted pyrazolo[1,5-a]pyrimidines for modulating CDK9 activity | Kronos Bio, Inc. (US) | 2021-10-26 | — | — | US | disclosed |
| EP-3873911-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CDK9 ACTIVITY | Kronos Bio, Inc. (US) | 2021-09-08 | — | — | EP | disclosed |
| US-20200131189-A1 | Compounds, Compositions, and Methods for Modulating CDK9 Activity | IGNOTA LABS LIMITED (GB) | 2020-04-30 | — | — | US | disclosed |
| US-20200131189-A1 | Compounds, Compositions, and Methods for Modulating CDK9 Activity | IGNOTA LABS LIMITED (GB) | 2020-04-30 | — | — | US | disclosed |
| WO-2019023654-A9 | DISCOVERY OF SMALL MOLECULES THAT TARGET THE ANDROGEN RECEPTOR AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2019-02-28 | — | — | WO | disclosed |
| WO-2019023654-A2 | DISCOVERY OF SMALL MOLECULES THAT TARGET THE ANDROGEN RECEPTOR AND USES THEREOF | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2019-01-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200131189-A1 | Compounds, Compositions, and Methods for Modulating CDK9 Activity | CDK9, CDK19, CDK7 | CDK9 1/4885CDK7 3/4885CDK2 8/4885 |
| US-20240132506-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CDK9 ACTIVITY | CDK9, CDK19, CDK7 | CDK9 1/4885CDK7 3/4885CDK2 8/4885 |
| US-11845754-B2 | Substituted pyrazolo[1,5-a]pyrimidines for modulating CDK9 activity | CDK9, CDK19, CDK7 | CDK9 1/4885CDK7 3/4885CDK2 9/4885 |
| US-20230158159-A1 | CHIMERIC DEGRADERS OF CYCLIN-DEPENDENT KINASE 9 AND USES THEREOF | CDK9, CDK19, CRBN | CDK9 1/4885CDK7 13/4885CDK2 11/4885 |
| US-20220002305-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CDK9 ACTIVITY | CDK9, CDK19, CDK7 | CDK9 1/4885CDK7 3/4885CDK2 8/4885 |
| US-11155560-B2 | Substituted pyrazolo[1,5-a]pyrimidines for modulating CDK9 activity | CDK9, CDK19, CDK7 | CDK9 1/4885CDK7 3/4885CDK2 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.