SCHEMBL2069366

SCHEMBL2069366

Cc1nc(-c2ccc(Cl)cc2)sc1C(=O)NC1CCCN(C(=O)OC(C)(C)C)C1

nearest known ligand 0.63

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PPARA Q07869 10/20 0.63
PPARD Q03181 6/20 0.59
PPARG P37231 2/20 0.59
CNR1 P21554 2/20 0.59
CNR2 P34972 2/20 0.59
HDAC4 P56524 1/20 0.52
HDAC6 Q9UBN7 1/20 0.52
USP30 Q70CQ3 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.50
CHRM4 P08173 1/20 0.49
GAA P10253 1/20 0.48
ANO1 Q5XXA6 2/20 0.48
PARP1 P09874 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2069528 1.00 PPARA (0.63) PPARAPPARDPPARGCNR1CNR2
SCHEMBL2069365 1.00 PPARA (0.63) PPARAPPARDPPARGCNR1CNR2
SCHEMBL2069460 0.86 CNR1 (0.52) PPARAPPARDPPARGCNR1CNR2
SCHEMBL2070349 0.85 PPARA (0.61) PPARAPPARDPPARGCNR1CNR2
SCHEMBL2069923 0.83 PPARA (0.61) PPARAPPARDPPARGCNR1CNR2
SCHEMBL2069575 0.82 MEN1 (0.48) PPARAPPARDPPARGSMN1; SMN2CHRM4
SCHEMBL2069312 0.82 PPARA (0.60) PPARAPPARDPPARGSMN1; SMN2CHRM4
SCHEMBL1564849 0.81 CNR1 (0.57) CNR1CNR2HDAC4HDAC6USP30
SCHEMBL17729070 0.80 USP30 (0.66) CNR1CNR2HDAC4HDAC6USP30
SCHEMBL27678378 0.79 PPARA (0.67) PPARAPPARDPPARGSMN1; SMN2CHRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7902367-B2 Cyclic amino benzoic acid derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2011-03-08 US disclosed
US-7902367-B2 Cyclic amino benzoic acid derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2011-03-08 US disclosed
US-20090036489-A1 Novel Cyclic Aminophenylalkanoic Acid Derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2009-02-05 US disclosed
US-20090036489-A1 Novel Cyclic Aminophenylalkanoic Acid Derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2009-02-05 US disclosed
US-20090036489-A1 Novel Cyclic Aminophenylalkanoic Acid Derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2009-02-05 US disclosed
EP-1862464-A1 NOVEL CYCLIC AMINOPHENYLALKANOIC ACID DERIVATIVE Kyorin Pharmaceutical Co., Ltd. (JP) 2007-12-05 EP disclosed
US-20070249580-A1 Novel Cyclic Amino Benzoic Acid Derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2007-10-25 US disclosed
US-20070249580-A1 Novel Cyclic Amino Benzoic Acid Derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2007-10-25 US disclosed
US-20070249580-A1 Novel Cyclic Amino Benzoic Acid Derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2007-10-25 US disclosed
EP-1780210-A1 NOVEL CYCLIC AMINOBENZOIC ACID DERIVATIVE Kyorin Pharmaceutical Co., Ltd. (JP) 2007-05-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090036489-A1 Novel Cyclic Aminophenylalkanoic Acid Derivative PPARA, PPARD, PPARG PPARA 1/4885PPARD 2/4885PPARG 3/4885
US-20070249580-A1 Novel Cyclic Amino Benzoic Acid Derivative PPARA, PPARG, PPARD PPARA 1/4885PPARD 3/4885PPARG 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.