SCHEMBL2069460

SCHEMBL2069460

Cc1nc(-c2ccc(Cl)cc2)sc1CC(=O)NC1CCCN(C(=O)OC(C)(C)C)C1

nearest known ligand 0.52

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CNR1 P21554 3/20 0.52
CNR2 P34972 3/20 0.52
ANO1 Q5XXA6 2/20 0.48
PPARA Q07869 7/20 0.48
USP30 Q70CQ3 3/20 0.47
HDAC4 P56524 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
AHCY P23526 1/20 0.45
PPARG P37231 1/20 0.45
PPARD Q03181 1/20 0.45
PARP1 P09874 1/20 0.43
PBK Q96KB5 1/20 0.42
TP53 P04637 1/20 0.41
THRB P10828 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2069528 0.86 PPARA (0.63) CNR1CNR2ANO1PPARAUSP30
SCHEMBL2069366 0.86 PPARA (0.63) CNR1CNR2ANO1PPARAUSP30
SCHEMBL2069365 0.86 PPARA (0.63) CNR1CNR2ANO1PPARAUSP30
SCHEMBL2069970 0.83 PPARA (0.61) CNR1CNR2PPARAPPARD
SCHEMBL2069948 0.83 PPARA (0.61) CNR1CNR2PPARAPPARD
SCHEMBL2070708 0.82 PPARA (0.48) CNR1CNR2PPARATP53THRB
SCHEMBL2069079 0.81 PPARA (0.48) CNR1CNR2PPARAPPARD
SCHEMBL2069575 0.78 MEN1 (0.48) PPARAPPARGPPARD
SCHEMBL2069584 0.78 PPARA (0.59) CNR1CNR2PPARA
SCHEMBL2070349 0.77 PPARA (0.61) CNR1CNR2PPARAPPARGPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7902367-B2 Cyclic amino benzoic acid derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2011-03-08 US disclosed
US-7902367-B2 Cyclic amino benzoic acid derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2011-03-08 US disclosed
US-20070249580-A1 Novel Cyclic Amino Benzoic Acid Derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2007-10-25 US disclosed
US-20070249580-A1 Novel Cyclic Amino Benzoic Acid Derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2007-10-25 US disclosed
US-20070249580-A1 Novel Cyclic Amino Benzoic Acid Derivative KYORIN PHARMACEUTICAL CO., LTD. (JP) 2007-10-25 US disclosed
CN-101014595-A Novel cyclic aminobenzoic acid derivative KYORIN SEIYAKU KK (JP) 2007-08-08 CN disclosed
EP-1780210-A1 NOVEL CYCLIC AMINOBENZOIC ACID DERIVATIVE Kyorin Pharmaceutical Co., Ltd. (JP) 2007-05-02 EP disclosed
EP-1780210-A1 NOVEL CYCLIC AMINOBENZOIC ACID DERIVATIVE Kyorin Pharmaceutical Co., Ltd. (JP) 2007-05-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070249580-A1 Novel Cyclic Amino Benzoic Acid Derivative PPARA, PPARG, PPARD CNR1 42/4885CNR2 101/4885ANO1 2629/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.