Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | PPARD | Q03181 | 3/20 | 0.38 |
| ▸ | PPARA | Q07869 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2719718 | 1.00 | ACE2 (0.47) | ACE2KMT2AMAPTCES2CES1 | |
| SCHEMBL8660353 | 0.94 | KMT2A (0.52) | ACE2KMT2AMAPTHAO1ALDH1A1 | |
| SCHEMBL12971057 | 0.92 | KMT2A (0.55) | ACE2KMT2AMAPTHAO1ALDH1A1 | |
| SCHEMBL12970932 | 0.92 | KMT2A (0.55) | ACE2KMT2AMAPTHAO1ALDH1A1 | |
| SCHEMBL8659413 | 0.92 | KMT2A (0.55) | ACE2KMT2AMAPTHAO1ALDH1A1 | |
| SCHEMBL8658977 | 0.92 | KMT2A (0.55) | ACE2KMT2AMAPTHAO1ALDH1A1 | |
| SCHEMBL27970840 | 0.86 | CYP1A2 (0.44) | ACE2CES2CES1CYP1A2TSHR | |
| Valeric Acid SCHEMBL28674089 | 0.81 | AKR1B1 (0.54) | ACE2KMT2AMAPTCYP1A2ALDH1A1 | |
| SCHEMBL21596754 | 0.80 | ACE2 (0.39) | ACE2KMT2AMAPTCES2CES1 | |
| SCHEMBL2049922 | 0.79 | CES1 (0.48) | ACE2KMT2AMAPTCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10925846-B2 | Phenylketone carboxylate compounds and pharmaceutical compositions for the prevention and treatment of osteoporosis | Liminal Biosciences Limited (GB) | 2021-02-23 | — | — | US | disclosed |
| US-20190038580-A1 | PHENYLKETONE CARBOXYLATE COMPOUNDS AND PHARAMCEUTICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF OSTEOPOROSIS | Liminal Biosciences Limited (GB) | 2019-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10925846-B2 | Phenylketone carboxylate compounds and pharmaceutical compositions for the prevention and treatment of osteoporosis | NCEH1, CTSH, BCKDK | ACE2 2926/4885KMT2A 1795/4885MAPT 3934/4885 |
| US-20190038580-A1 | PHENYLKETONE CARBOXYLATE COMPOUNDS AND PHARAMCEUTICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF OSTEOPOROSIS | PAH, NCEH1, CCNH | ACE2 2449/4885KMT2A 1568/4885MAPT 3324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.