Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 13/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19423082 | 0.84 | HSD11B1 (0.44) | HSD11B1NPC1 | |
| SCHEMBL19423132 | 0.84 | HSD11B1 (0.50) | HSD11B1HTR7 | |
| SCHEMBL20708038 | 0.84 | HSD11B1 (0.51) | HSD11B1HTR7KCNH2 | |
| SCHEMBL24167463 | 0.81 | HSD11B1 (0.73) | HSD11B1KCNH2 | |
| SCHEMBL20708031 | 0.81 | HSD11B1 (0.47) | HSD11B1HTR7KDM4E | |
| SCHEMBL20707997 | 0.79 | PDE4A (0.46) | HSD11B1HTR7 | |
| SCHEMBL20708051 | 0.78 | TUBB1 (0.47) | HSD11B1HTR7 | |
| SCHEMBL20708009 | 0.77 | HSD11B1 (0.44) | HSD11B1NPC1HTR7KDM4E | |
| SCHEMBL20708032 | 0.77 | HSD11B1 (0.43) | HSD11B1HTR7 | |
| SCHEMBL20707981 | 0.77 | POLB (0.50) | HSD11B1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3438105-A1 | DIARYL- -LACTAM COMPOUND AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | Fudan University (CN) | 2019-02-06 | — | — | EP | disclosed |