Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4941538 | 0.92 | MAPT (0.56) | GPR119MAPTLMNAALDH1A1MEN1 | |
| Piperazine SCHEMBL27197226 | 0.85 | MAPT (0.50) | GPR119MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL31036793 | 0.85 | MAPT (0.50) | GPR119MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL3753571 | 0.85 | MAPT (0.50) | GPR119MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL23228913 | 0.84 | GPR119 (0.51) | GPR119MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL19404228 | 0.84 | TTR (0.51) | GPR119MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL13550026 | 0.84 | GPR119 (0.53) | GPR119MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL19404281 | 0.83 | GPR119 (0.52) | GPR119MAPTLMNAALDH1A1MEN1 | |
| SCHEMBL30976319 | 0.82 | EGLN2 (0.53) | GPR119MAPTLMNAALDH1A1PDK2 | |
| SCHEMBL19404303 | 0.82 | MAPT (0.47) | GPR119MAPTLMNAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3237406-B1 | 5-[(PIPERAZIN-1-YL)-3-OXO-PROPYL]-IMIDAZOLIDINE-2,4-DIONE DERIVATIVES AS ADAMTS INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | GALAPAGOS NV (BE) | 2019-02-06 | — | — | EP | disclosed |