Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 6/20 | 0.57 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.49 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.49 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.49 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | WNT3A | P56704 | 3/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2072260 | 0.94 | HPGDS (0.61) | HPGDSBMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL2070565 | 0.87 | HPGDS (0.63) | HPGDSMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2072599 | 0.86 | HPGDS (0.60) | HPGDSBMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL2072035 | 0.84 | HPGDS (0.59) | HPGDSMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2071807 | 0.84 | HPGDS (0.61) | HPGDSMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2070294 | 0.83 | HPGDS (0.65) | HPGDSMEN1KMT2AUSP30MAP4K4 | |
| SCHEMBL2070380 | 0.82 | HPGDS (0.60) | HPGDSMEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL2984433 | 0.82 | HPGDS (0.63) | HPGDSBMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL2984429 | 0.82 | HPGDS (0.63) | HPGDSBMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL2985442 | 0.82 | HPGDS (0.63) | HPGDSBMPR1BBMPR1ATGFBR1ACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7902373-B2 | asthma; for treating prostaglandin D2 mediated diseases; e.g. 6-(3-fluorophenyl)-N-[1-(1-methyl-1H-tetrazol-5-yl)piperidin-4-yl]nicotinamide | PFIZER INC (US) | 2011-03-08 | — | — | US | disclosed |
| US-20080146569-A1 | Nicotinamide Derivatives | PFIZER INC. | 2008-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080146569-A1 | Nicotinamide Derivatives | NNT, NAMPT, NADK | HPGDS 984/4885BMPR1B 3847/4885BMPR1A 4320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.