Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GGPS1 | O95749 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 3/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.43 |
| ▸ | PPARA | Q07869 | 2/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2070993 | 1.00 | GGPS1 (0.49) | GGPS1KMT2APTPN1BACE1MEN1 | |
| SCHEMBL19664772 | 0.84 | PPARG (0.58) | GGPS1KMT2APTPN1BACE1MEN1 | |
| SCHEMBL5823582 | 0.84 | PPARG (0.58) | GGPS1KMT2APTPN1BACE1MEN1 | |
| SCHEMBL2072104 | 0.84 | KMT2A (0.52) | GGPS1KMT2APTPN1BACE1MEN1 | |
| SCHEMBL2072101 | 0.84 | KMT2A (0.52) | GGPS1KMT2APTPN1BACE1MEN1 | |
| SCHEMBL28252862 | 0.83 | PPARG (0.57) | GGPS1KMT2APTPN1BACE1MEN1 | |
| SCHEMBL31670205 | 0.82 | TRPV1 (0.56) | GGPS1KMT2APTPN1BACE1MEN1 | |
| SCHEMBL793954 | 0.82 | TRPV1 (0.56) | GGPS1KMT2APTPN1BACE1MEN1 | |
| SCHEMBL9953748 | 0.82 | TRPV1 (0.56) | GGPS1KMT2APTPN1BACE1MEN1 | |
| SCHEMBL11768068 | 0.81 | TRPV1 (0.50) | GGPS1KMT2APTPN1BACE1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732915-B1 | SCHWEINFURTHIN ANALOGUES | UNIV IOWA RES FOUND (US) | 2016-01-06 | — | — | EP | disclosed |
| US-20110319481-A1 | SCHWEINFURTHIN ANALOGUES | Government of the United States of America, National Institute of Health (US) | 2011-12-29 | — | — | US | disclosed |
| US-7902228-B2 | such as: 3-Deoxyschweinfurthin B; anticancer assay; e.g. breast cancer or a cancer of the CNS or renal system diagnosis | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2011-03-08 | — | — | US | disclosed |
| US-20080227852-A1 | SCHWEINFURTHIN ANALOGUES | THE GOVERNMENT OF THE UNITED STATES OF AMERICA | 2008-09-18 | — | — | US | disclosed |
| US-7358377-B2 | such as: 3-Deoxyschweinfurthin B; tested and were found to have anti-cancer by NCI 60-cell line anticancer assay; e.g. breast cancer or a cancer of the CNS or renal system | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2008-04-15 | — | — | US | disclosed |
| US-20080015232-A1 | SCHWEINFURTHIN ANALOGUES | US GOVERNMENT - SECRETARY FOR THE ARMY | 2008-01-17 | — | — | US | disclosed |
| EP-1732915-A2 | SCHWEINFURTHIN ANALOGUES | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005092878-A2 | SCHWEINFURTHIN ANALOGUES | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2005-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015232-A1 | SCHWEINFURTHIN ANALOGUES | ERH, HRAS, HNRNPH1 | GGPS1 777/4885KMT2A 1798/4885PTPN1 4847/4885 |
| US-20080227852-A1 | SCHWEINFURTHIN ANALOGUES | ERH, HRAS, HNRNPH1 | GGPS1 777/4885KMT2A 1798/4885PTPN1 4847/4885 |
| US-20110319481-A1 | SCHWEINFURTHIN ANALOGUES | ERH, HRAS, HNRNPH1 | GGPS1 777/4885KMT2A 1798/4885PTPN1 4847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.