Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 10/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.43 |
| ▸ | BRAF | P15056 | 6/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | STK4 | Q13043 | 1/20 | 0.41 |
| ▸ | STK3 | Q13188 | 1/20 | 0.41 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.41 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.41 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17529301 | 0.84 | BRAF (0.49) | CDK1KDRBRAF | |
| SCHEMBL17047522 | 0.82 | PIK3CG (0.59) | CDK1KDRPIK3CGPIK3CABRAF | |
| SCHEMBL7153086 | 0.82 | ROCK1 (0.47) | CDK1KDRPIK3CGPIK3CAPIK3CD | |
| SCHEMBL17047483 | 0.81 | PIK3CG (0.50) | KDRPIK3CGPIK3CABRAFPIK3CD | |
| SCHEMBL17047495 | 0.81 | BRAF (0.63) | PIK3CGPIK3CABRAF | |
| SCHEMBL12120858 | 0.80 | BRAF (0.53) | CDK1KDRBRAF | |
| SCHEMBL17047502 | 0.78 | PIK3CA (0.47) | PIK3CGPIK3CABRAFPIK3CDPIK3CB | |
| SCHEMBL5495505 | 0.78 | ADRB2 (0.58) | CDK1KDRBRAFGSK3AGSK3B | |
| SCHEMBL17047457 | 0.78 | PIK3CA (0.66) | CDK1KDRPIK3CGPIK3CABRAF | |
| SCHEMBL17047547 | 0.78 | BRAF (0.57) | PIK3CGPIK3CABRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10202374-B2 | 6-aryl-4-phenylamino-quinazoline analogs as phosphoinositide-3-kinase inhibitors | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2019-02-12 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10202374-B2 | 6-aryl-4-phenylamino-quinazoline analogs as phosphoinositide-3-kinase inhibitors | PIK3CA, PI4KA, PDPK1 | CDK1 100/4885KDR 1495/4885PIK3CG 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.