Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 6/20 | 0.39 |
| ▸ | RAB9A | P51151 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16200827 | 0.81 | DRD2 (0.43) | APPDRD2DRD4DRD3KDM4E | |
| SCHEMBL973963 | 0.81 | DRD2 (0.43) | APPDRD2DRD4DRD3KDM4E | |
| SCHEMBL13633339 | 0.81 | NPC1 (0.52) | APPKDM4ETP53NPC1RAB9A | |
| SCHEMBL10222603 | 0.79 | KDM4E (0.44) | APPKDM4ETP53NPC1RAB9A | |
| SCHEMBL31210804 | 0.78 | APP (0.43) | APPKDM4ETP53NPC1RAB9A | |
| SCHEMBL13080964 | 0.78 | APP (0.46) | APPKDM4ETP53NPC1RAB9A | |
| SCHEMBL1500151 | 0.78 | PIK3CG (0.55) | APPDRD2DRD4DRD3KDM4E | |
| SCHEMBL8180039 | 0.78 | GRM5 (0.47) | APPDRD2DRD4DRD3KDM4E | |
| SCHEMBL8814958 | 0.78 | KDM4E (0.68) | APPKDM4ETP53NPC1RAB9A | |
| SCHEMBL423547 | 0.76 | NPC1 (0.58) | KDM4ETP53NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019028362-A1 | INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | DYAX CORP. (US) | 2019-02-07 | — | — | WO | disclosed |