Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 17/20 | 0.40 |
| ▸ | MAT2A | P31153 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20705232 | 0.83 | KLKB1 (0.38) | KLKB1 | |
| SCHEMBL20713756 | 0.82 | KLKB1 (0.38) | KLKB1 | |
| SCHEMBL21367965 | 0.82 | KLKB1 (0.44) | KLKB1 | |
| Hydrochloric Acid SCHEMBL21355106 | 0.81 | KLKB1 (0.38) | KLKB1 | |
| Hydrochloric Acid SCHEMBL21355328 | 0.81 | KLKB1 (0.38) | KLKB1 | |
| SCHEMBL21893418 | 0.81 | KDM4E (0.37) | GABRA1GABRG2GABRB3GABRA5KLKB1 | |
| SCHEMBL21355378 | 0.80 | KLKB1 (0.37) | KLKB1 | |
| SCHEMBL21368385 | 0.80 | KLKB1 (0.43) | KLKB1 | |
| SCHEMBL23088689 | 0.79 | KLKB1 (0.43) | KLKB1 | |
| Hydrochloric Acid SCHEMBL21355223 | 0.79 | KLKB1 (0.36) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019178129-A1 | SUBSTITUTED IMIDAZOPYRIDINES AS INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | SHIRE HUMAN GENETIC THERAPIES, INC. (US) | 2019-09-19 | — | — | WO | disclosed |
| WO-2019028362-A1 | INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | DYAX CORP. (US) | 2019-02-07 | — | — | WO | disclosed |