Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 7/20 | 0.43 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.37 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
| ▸ | NAA50 | Q9GZZ1 | 1/20 | 0.34 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | CPT2 | P23786 | 1/20 | 0.32 |
| ▸ | CPT1A | P50416 | 1/20 | 0.32 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20713640 | 0.84 | KLKB1 (0.55) | KLKB1TRPC3TRPC6 | |
| SCHEMBL20713726 | 0.83 | BAZ2A (0.43) | KLKB1TRPC3TRPC6TRPV1TRPA1 | |
| SCHEMBL20713811 | 0.83 | TRPC3 (0.43) | KLKB1TRPC3TRPC6TRPV1TRPA1 | |
| SCHEMBL20713814 | 0.83 | TRPC3 (0.43) | KLKB1TRPC3TRPC6TRPV1TRPA1 | |
| SCHEMBL20713771 | 0.83 | TRPC3 (0.42) | KLKB1TRPC3TRPC6TRPV1ACKR3 | |
| SCHEMBL20713774 | 0.83 | ACKR3 (0.44) | KLKB1TRPV1BAZ2AACKR3NAA50 | |
| SCHEMBL20713724 | 0.82 | KLKB1 (0.51) | KLKB1 | |
| SCHEMBL20713642 | 0.81 | KLKB1 (0.40) | KLKB1TRPV1BAZ2AACKR3NAA50 | |
| SCHEMBL20713881 | 0.81 | KLKB1 (0.38) | KLKB1TRPV1BAZ2AACKR3NAA50 | |
| SCHEMBL20713770 | 0.81 | SMN1; SMN2 (0.44) | KLKB1TRPC3TRPC6BAZ2AHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019028362-A1 | INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | DYAX CORP. (US) | 2019-02-07 | — | — | WO | disclosed |