Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 17/20 | 0.55 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.41 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20713648 | 0.92 | KLKB1 (0.64) | KLKB1 | |
| SCHEMBL20713763 | 0.92 | KLKB1 (0.64) | KLKB1 | |
| SCHEMBL20713816 | 0.90 | KLKB1 (0.52) | KLKB1EGLN1 | |
| SCHEMBL20713727 | 0.90 | KLKB1 (0.52) | KLKB1 | |
| SCHEMBL20713724 | 0.89 | KLKB1 (0.51) | KLKB1 | |
| SCHEMBL20713634 | 0.84 | KLKB1 (0.43) | KLKB1TRPC3TRPC6 | |
| SCHEMBL20713771 | 0.82 | TRPC3 (0.42) | KLKB1TRPC3TRPC6 | |
| SCHEMBL20713642 | 0.79 | KLKB1 (0.40) | KLKB1 | |
| SCHEMBL20713774 | 0.78 | ACKR3 (0.44) | KLKB1 | |
| SCHEMBL20713881 | 0.78 | KLKB1 (0.38) | KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019028362-A1 | INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF | DYAX CORP. (US) | 2019-02-07 | — | — | WO | disclosed |